Study On The Changes Of Serum Trace Elements In Children With Tourette Syndrome And The Relationship Between Trace Elements And Tourette Syndrome

Objective:To explore the changes of serum levels of lead,copper,zinc,iron,and magnesium in children with Tourette's syndrome,and the relationship between the levels of lead,copper,zinc,iron,and magnesium in serum.Methods:Selected 200 children with Tourette syndrome from October 2013 to December 2016 in our hospital,selected the same period in our hospital for physical examination of children in 100 cases.Accorded to whether the children with Tourette syndrome,the subjects were divided into tic group and control group;Accorded to the gender of children,the children with tic disorder were divided into male group and female group;Accorded to the age of children,the children with tic disorder were divided into young group,preschool group,school-age group;Accorded to the severity of tic disorder in children,the children with tic disorder were divided into mild impulsivity group,mild tic group,moderate tic group,significant tic group and severe tic group.The levels of lead,copper,zinc,iron,and magnesium in serum were determined by atomic absorption spectrometry.The levels of lead,copper,zinc,iron,and magnesium in serum of each group were compared,and the correlation between serum lead,copper,zinc,iron,and magnesium was analyzed by Logistic regression analysis.Results:(1)There were no significant difference in the general clinical data between the tic group and the control group(P>0.05);(2)The levels of lead,zinc and iron in children with Tourette syndrome(P<0.05)were significantly different from those in the control group(P<0.05).There were no significant difference in serum copper,magnesium levels between the control group and the control group;(3)The incidence of lead,zinc and iron in children with Tourette syndrome was significantly higher than that in control group(P<0.05);(4)The levels of lead,copper,zinc,iron,and magnesium in young children,preschool and school-age children were not significantly different from those in the control group(P>0.05);(5)The levels of lead,copper,zinc,iron,and magnesium in the serum of male and female tic group were not significantly different from those of the control group(P>0.05);(6)Slight impulse disorder group and mild group,moderate tic tic tic group,obvious group and severe Tourette syndrome group of lead,zinc and iron levels have significant difference(P<0.05),slight impulse disorder group and mild group,moderate tic tic tic group group,obvious and serious tic copper and magnesium levels in serum of no significant difference(P<0.05);(7)Low levels of zinc and iron are risk factors for Tourette syndrome in children,and high levels of lead are risk factors for Tourette syndrome in children.Conclusions:(1)The blood lead level in children with tic disorder is higher than that in normal children;(2)The serum levels of zinc and iron in children with tic disorders are lower than those in normal children;(3)The levels of copper,magnesium in serum of children with tic disorder are not significantly different from those of normal children.