Clinical Study In Treating Idiopathic Membranous Nephropathy By The Tonifying Kindney,Clearing Heat,Draining Dampness And Activating Blood Therapry

Object:To observe the effectiveness of the Tonifying Kindney,Clearing Heat,Draining Dampness and Activating Blood Therapry for Idiopathic Membranous Nephropathy(IMN).To explore the feasibility of the therapy from the theories of Traditional Chinese Medicine(TCM).To summarize the key features of the therapry.Methods:This study is composed of two parts:theoretical analysis and clinical research.The theoretical part is to collect and analyze all public literature to summarize the theories about IMN in TCM and Western Medicine.In clinical research,we collected 40 IMN patients who received TCM treatment by the Tonifying Kindney,Clearing Heat,Draining Darmpness and Activating Blood Therapry combined with basic treatment of Western Medicine for 6 months.The effectivenss of the therapy was evaluated by observing the changes of clinical indexes and symptoms of these patients.The experience of Prof.Sun on the therapy for the treatment of IMN will also be summarized.Results:1.Symptomatic Effectiveness:After 6 months of treatment,the clinical symptom score of 38 patients was significantly lower than those before(P<0.05).The response rate is 82.5%.The symptoms including pain in lumbar and waist,fatigue,edema,lack of Qi,feverish palms and soles,no desire to speak and heavy cumbersome limbs were relieved significantly(P<0.05).2.Clinical Effectiveness:In all the 40 cases,6 patients had complete remissed(15%)and 28 patients had partial remissed after treatment(70%).There are 6 non-remission cases(15%)in the study.Clinical total effective rate is 85%.Patients,indexes of UTP,D-D,TC and TG decreased after treatment(the first three indexes significantly decreased,P<0.05).Patients,plasma albumin level significantly increased(P<0.05)and the level of Scr was kept within a normal range(P>0.05).3.Safety indexes:No obvious adverse events occurred during the treatment.The safety indexes(including K+,ALT,AST and Hb)were kept within a healthy range.The difference of these indexes before and after the treatment was not statistically significant(P>0.05).Conclusion:The Tonifying Kindney,Clearing Heat,Draining Dampness and Activating Blood Therapry can significantly improve the clinical symptoms of the IMN patients.The therapy can also reduce proteinuria,regulate lipid metabolism and anticoagulate in 6 months treatment.It also plays an important role in promoting plasma albumin and stabilizing renal function.In addition,this treatment is safe in clinical practice.