The Mechanism Of PEDF In Propranolol Treatment Of Infantile Hemangioma

Objective: To investigate the changes of serum levels of pigment epithelium-derived factor(PEDF)in the infantile hemangioma before and after treatment of propranolol,and to explore the mechanism of propranolol in the treatment of infantile hemangioma.Methods: Collect 35 cases of proliferating infantile hemangioma,17 cases of involuting infantile hemangioma,7 cases of vascular malformation and 10 patients of cleft lip and palate as a normal control group.The patients of proliferating infantile hemangioma and involuting infantile hemangioma were given propranolol treatment,collected blood samples from each group.Serum PEDF levels in each groups were studyed by human PEDF-ELISA kit,and used SPSS 21.0 statistical software to analyze.Results: The level of serum PEDF in the proliferating infantile hemangioma group(before treatment)was lower than the other three groups(P <0.05),The serum PEDF level in the involuting infantile hemangioma group was higher than the other three groups(P <0.05);The level of serum PEDF in the proliferating infantile hemangioma before treatment was lower than 1,3,6,9 months after treatment,P <0.01;the level of serum PEDF in the involuting infantile hemangioma before treatment was lower than 1,3 months after treatment.According to different classification,gender and age of the proliferating and involuting infantile hemangioma,no significant difference in the serum PEDF level before and after by propranolol treatment.Conclusion: This research confirmed that the changes of PEDF in the treatment of infantile hemangioma by propranolol,showed that the PEDF played an important role in occurrence and regression of infantile hemangioma.