Clinical Features And Imaging Features Of Neuromyelitis Optica Spectrum Disease With Systemic Autoimmune Diseases

ObjectiveTo explore the clinical features and imaging features of neuromyelitis optica spectrum disease(diagnosis with 2015 IPND diagnostic criteria)with systemic autoimmune diseases.MethodSixty-two NMOSD patients without systemic autoimmune diseases(n=62)and with systemic autoimmune diseases(n=19)were enrolled.The clinical,laboratory and magnetic resonance imaging features between two groups were assessed.ResultAmong the 81 patients with NMOSD,23.4%(19/81)were with systemic autoimmune diseases and 76.5%(62/81)were without systemic autoimmune diseases.Several autoantibodies seropositivity were significantly higher in NMOSD patients with systemic autoimmune diseases(p<0.05).Compared with NMOSD patients without systemic autoimmune diseases,NMOSD patients with systemic autoimmune diseases more frequently had longer spinal cord lesion in MRI(5.64±2.73 vs 4.13±2.21,p=0.039)and less frequency of cervical lesion extending into the medulla(0/14 vs 13/53,p=0.040).No difference was found in other clinical,imaging and laboratory characteristics between different NMOSD subtypes.ConclusionThe characteristics between NMOSD without and with systemic autoimmune diseases were similar.NMOSD with SADs high frequency of autoantibody seropositive,longer spinal cord lesion in MRI and less frequency of cervical lesion extending into the medulla.