The Correlation Between Serum Magnesium And Chronic Kidney Disease Complications

Objective:The aim of this study is to analysis retrospectively serum magnesium ion concentration in different stages of patients with chronic kidney disease,to investigate the relationship among serum magnesium and mineral metabolism disorders,valvular calcification,nutritional status in patients with chronic kidney disease.Method:We choose 392 patients with chronic kidney disease patients in the first hospital of Jilin University from April 2014 to December 2016,including 145 cases of non dialysis patients,to calculate glomerular filtration rate according MDRD,non dialysis patients were divided into CKD1 group(25 cases),CKD2 group(21 cases)and group CKD3(22 cases),CKD4 group(33 cases),CKD5 group(without renal replacement therapy,44 cases)and 5 groups of dialysis patients in 247 cases(191 hemodialysis patients,56 cases of peritoneal dialysis),a total of 6 groups were retrospectively analyzed.We collected and arranged clinical data and clinical index.We analyzed the relationship between serum magnesium and other related factors in patients with chronic kidney disease.Use SPSS 18.0 software packages for data analysis.Results: 1.We analyzed the data of 392 patients with chronic kidney disease,the average age of the patients in the study group was 53.86 + /-15.26 years old.In our study,there were 231 cases of male,accounting for 58.93%,161 cases of female,accounting for 41.07%.The patients with history of hypertension in 144 cases accounted for a total of 36.8%,and with a history of diabetes in 103 cases accounted for a total of 26.3%.2.We analyzed the distribution of serum magnesium ion and the relationship between serum magnesium levels and e GFR.The results showed that 145 patients in group CKD1-5 with low serum magnesium in 9 cases(6.21%),normal blood magnesium in 96 cases(66.21%),40 cases(27.58%)with high magnesium.Dialysis group 247 cases of patients with low serum magnesium in 26 cases(10.53%),normal blood magnesium in 136 cases(55.06%),85 cases(34.41%)with high magnesium.Hypermagnesemia patients occupied in the hemodialysis group was significantly higher than the proportion of peritoneal dialysis,and patients with low serum magnesium in abdominal dialysis group occupies a relatively high proportion,the difference was statistically significant(P = 0.001).With the decrease of glomerular filtration rate,serum magnesium ion content increases gradually,the difference was statistically significant(P <0.001).3.We analyzed the relationship between serum magnesium ion and CKD in patients with disordered mineral metabolism,the results showed that serum magnesium ion increased in patients with non dialysis,serum phosphorus(P<0.001)and PTH(P=0.027)were also increased,the content of serum magnesium ion in low calcium phosphorus product group was significantly lower than that in high calcium phosphorus product group,the difference was statistically significant(P= 0.001).The serum magnesium ion in dialysis patients increased,serum calcium(P=0.001),P(P=0.001)and PTH(P=0.013)were also increased.The serum magnesium phosphorus product in patients with CKD was positively related to calcium and phosphorus products,and the difference was statistically significant(P<0.001).The magnesium phosphorus product in non dialysis patients was positively related to PTH,and the difference was statistically significant(P=0.016).There was a positive correlation between calcium and magnesium products and calcium and phosphorus products in non dialysis patients,and the difference was statistically significant(P<0.001).4.We analyzed the relationship between serum magnesium ion and CKD in patients with valvular calcification,showed that patients with severe cardiac valve calcification in patients,the proportion had increased,but the difference was not statistically significant(P=0.660).By logistic regression analysis we confirmed that age,high PTH value and the history of diabetes is independent risk factors of CKD patients with heart valve calcification,but we did not find the relationship between serum magnesium level and cardiac valve calcification(P= 0.198).5.We analyzed the association between serum magnesium and nutritional status in patients with CKD,and found no association between nutritional status and serum magnesium levels(P>0.05).In patients with dialysis,with the deterioration of nutritional status,the level of magnesium ions showed a gradual downward trend(P<0.001).We found no association between serum magnesium and cholesterol,triglycerides,and high and low density lipoprotein(P> 0.05).6.Logistic regression model was used to analyze the factors of serum magnesium levels in patients with CKD,and the results showed that long months of dialysis were independent risk factors for high serum magnesium levels in patients with CKD.Hyperamgnesemnin patients occupied in the hemodialysis group was significantly higher than that in peritoneal dialysis patients,the difference was statistically significant(P = 0.001).Conclusions: 1.There was a negative correlation between the level of serum magnesium ion and e GFR in patients with stage CKD1-5.2.Serum magnesium may play a role in the occurrence and development of CKD-MBD.3.Serum magnesium ion levels have been found to be associated with Mineral metabolism disorder in patients with CKD,serum magnesium ion levels have not been found to be associated with valvular calcification in patients with CKD,there was a positive correlation between the level of magnesium ion and nutritional status in dialysis patients.4.Long months of dialysis was the independent risk factors of high magnesium content in serum of CKD patients.