The Research Of Brain Function Changes In The Patients With Obstructive Sleep Apnea–hypopnea Syndrome Based On ALFF,and Clinical Associational Analysis

Objective: To explore the differences of spontaneous activity of neurons in the brain between normal and patients with obstructive sleep apnea–hypopnea syndrome(OSAHS),further detect the relationship between the differences and the severity of the disease.Methods: 30 patients with obstructive sleep apnea–hypopnea syndrome and 23 healthy controls were collected,all patients were scanned resting-state functional magnetic resonance imaging(rs-fMRI)and assessed by MontrealCognitiveAssessment(MoCA).The OSAHS group were measured upper airway by CT for 8 hours before MRI examination,after received polysomnography.To analyze the correlation and the differences of the two groups.Results: Compared with the HC group,the patients with OSAHS showed significantly increased amplitude of low frequency fluctuation(ALFF)values in the bilateral parahippocampal gyrus,temporal lobe,fusiform gyrus,right frontal lobe and left cerebellum,the difference was statistically significant(P<0.005);the OSAHS group showed significantly decreased ALFF values in the bilateral parietal lobe,bilateral brainstem,the bilateral posterior cingulate cortex and precuneus,the difference was statistically significant(P<0.005);Pearson correlation analysis results,the ALFF values in bilateral parahippocampal gyrus,temporal lobe,fusiform gyrus was negatively correlated with airway stenosis;the ALFF values in the bilateral superior parietal lobule was negatively correlated with apnea hypoventilation index of OSAHS(P<0.005);the ALFF values in the bilateral posterior cingulate cortex and precuneus was positively correlated with the MoCA score(P<0.005).Conclusion: fMRI technique was able to detect the changes of brain function in OSAHS patients,providing an effective imaging way for the identification and diagnosis of OSAHS patients and healthy controls.