| 1.TCM syndrome investigation1.1 Objective: To study the distribution of TCM syndromes in children with cough variant asthma and to explore the correlation of symptoms and syndromes,and to provide evidence for the diagnosis and treatment of children with cough variant asthma and TCM syndrome differentiation.1.2 Methods: Questionnaires by way of 167 children with cough variant asthma in children with the general situation and the main symptoms were collected,the establishment of relevant databases,and according to the frequency of symptoms using SPSS19.0 statistical software were clustering analysis and the main Component analysis.1.3 Results: The survey of 167 patients with CVA in children,male to female ratio of 1.11: 1,mainly concentrated in the age of 3-6 years,mainly concentrated in the 1-3 months.(38.3%,27.5%,19.2%)were found in 64 cases,46 cases,32 cases and 25 cases,respectively,in the syndrome of lung-spleen-kidney syndrome,wind-heat attacking lung syndrome,15.0%.Cluster analysis and principal component analysis of frequency of symptoms were consistent with the results of the main syndromes.1.4 Conclusion: Cough variant asthma in children with lung and spleen deficiency syndrome and wind-heat attack syndrome is more,the incidence of predisposing factors mainly associated with respiratory infections,allergic disease,personal history of increased risk of allergies in children,the syndrome type And the main symptoms and tongue closely related to pulse.2.Clinical researches2.1 Objective: To observe the effect of Jianpi Bufei Huatan Recipe on LTC4,1,25-(OH)2D3 levels and recurrence rate in children with cough variant asthma and lung spleen-qi deficiency syndrome in order to evaluate the clinical effect On the effectiveness and safety,while Jianpi Bufei Huatanfang prevention and treatment of CVA-related mechanisms to explore the future for the clinical application to provide a reliable basis for the promotion.2.2 Methods: 60 cases of spleen qi deficiency type CVA children were randomly divided into treatment group and control group.The control group(n = 30)was treated with fluticasone aerosol,on demand salbutamol aerosol.30 patients in the treatment group were treated with Jianpi Bufei Huatan Decoction on the basis of the control group.They were given orally twice a day for 2 weeks.The course of treatment lasted for 2 courses.After the end of each course of treatment,the curative effect was evaluated.The levels of LTC4,1,25-(OH)2D3 in the peripheral blood of the two groups were measured before treatment and on the last day of the second course of Chinese medicine.At the end of the total course of treatment follow-up three months,compare the treatment group and the control group relapse rate.2.3 Results2.3.1 Overall efficacy assessmentAfter the end of the total treatment,30 cases of clinical control,clinical control in 17 cases,markedly effective in 11 cases,effective in 2 cases,0 cases,the total effective rate was 100%,control rate was 93.33%;30 cases of control,clinical control 14 cases,markedly effective in 8 cases,effective in 7 cases,1 cases,the total effective rate of 96.67%,control rate was 73.33%.There was no significant difference in the total effective rate between the two groups(P> 0.05).There was significant difference in the control and markedly effective rate between the two groups(P <0.05).2.3.2 Jianpi Bufei Huatan Recipe on CVA in children with TCM syndrome scoreAfter a course of treatment,the treatment group and the control group and the treatment of the two groups of TCM syndrome scores before and after comparison,the difference was significant(P< 0.05),after two courses of treatment group and control group,two groups before and after treatment of TCM syndrome integral comparison,the difference was significant(P<0.05),TCM syndrome score suggesting that this treatment can improve CVA patients.There was significant difference in the total effective rate of syndrome between the treatment group and the control group(P <0.05).2.3.3 Jianpi Bufei Huatan Recipe on CVA in children with serum LTC4 and 1,25-(OH)2D3 effectThere was no significant difference in the level of LTC4 between the two groups after treatment(P> 0.05).The level of LTC4 in the peripheral blood of the control group after treatment for 2 courses was not statistically significant compared with that before treatment(P > 0.05).The level of LTC4 in the peripheral blood of the treatment group was no significant difference compared with that before treatment(P> 0.05).The treatment group after 2 courses of treatment,the peripheral blood 1,25-(OH)2D3 levels were statistically significant compared with before treatment(P < 0.05).The control group after 2 courses of treatment,the peripheral blood 1,25-(OH)2D3 levels were not statistically significant compared with before treatment(P > 0.05).The treatment group after treatment for 2 weeks,peripheral blood 1,25-(OH)2D3,compared with the control group,the difference was statistically significant(P < 0.05).2.3.4 Jianpi Bufei Huatan Recipe on CVA in children with the recurrence rateThe total course of follow-up three months after the end of treatment group 2 cases of recurrence,the recurrence rate was 6.67%,control group 6 cases of recurrence,the recurrence rate was 20%,with statistically significant difference between the two groups(P > 0.05)In this study,a total of 30 patients in the treatment group were completed.During the trial,the clinical data of the 0 patients were withdrawn,and no adverse reactions were observed in the clinical observation.2.4 Conclusion: Jianpi Bufei Huantan Recipe can improve CVA children’s traditional Chinese medicine syndrome points,enhance children’s physique,improve the overall efficacy and improve serum levels of 1,25-(OH)2D3,but the serum LTC4 content in children without The results showed that Jianpi Bufei Huatan Decoction was effective in treating cough variant asthma in children with spleen-qi deficiency syndrome,and could reduce the relapse after stopping drug treatment.It is safe and worthy to be popularized in clinical practice. |
PDF Full Text Request