The Effect Of Different Doses Of Rosuvastatin On Myocardial Injury And Inflammation Factors In Patients With Unstable Angina Pectoris Undering Percutaneous Coronary Intervention

Objective:Patients with Unstable angina pectoris undergoing elective percutaneous coronary intervention(PCI)were treated with different doses of rosuvastatin before PCI,and observe the levels of c Tn I and CK-MB.At the same time,we observe the changes of inflammatory factor C(hs-CRP)to explore the effects of different doses of rosuvastatin on myocardial protection,inflammatory factors and the safety of rosuvastatin in patients undergoing elective PCI.Methods: 80 patients with unstable angina pectoris were selected from the Department of cardiovascular surgery From June 2015 to December 2016,and they were enrolled in the Department of Cerebrovascular Disease,Yan'an University.The patients were randomly divided into group A(20mg/d)and group B(10mg/d),each group received 40 cases with randomization.The patients of group A take 20 mg of rosuvastatin once-daily three days before the surgery,and we recommend that patients take the medicine at the night.The group B patients was treated with rosuvastatin calcium tablets 10 mg daily at 3 days before operation.Each group of patients change the dose of the medicine to 10 mg long term service after the surgery.Each patient after admission need to be collected the levels of c Tn I,CK-MB and hs-CRP,respectively before PCI,6h and 24 h after PCI.Blood lipid index such as TC and TG and LDL-C as well as HDL-C were measured before and 15 days after operation.And observe the occurrence of postoperative side effects of statins and 1 months postoperative adverse cardiovascular events.The data obtained were made further analysis by SPSS20.0 statistical package.Result: 1.The clinical data of patients in each group were compared,and the difference was not statistically significant in cardiovascular risk factors(P > 0.05).2.The levels of ??-?B and ?Tn? between the two groups were not statistically significant before surgery(P>0.05).The markers of myocardial injury were increased 6 hours after PCI,but there was no significant difference between the two groups(P> 0.05).24 hours after PCI,the group B was significantly higher than group A in the levels of ??-?B and ?Tn?(P <0.05).The levels of ??-?B and ?Tn? at 6h and 24 h after PCI in group A and group B were higher than those before operation,and the difference was statistically significant(P <0.05).3.The levels of serum Hs-CRP between the two groups were not statistically significant before and 6h after PCI(P>0.05).24 h After PCI,the levels of Hs-CRP in each group was higher than that in the admission group,and the group B was significantly higher than the group A(P <0.05).The levels of serum hs-CRP in group A and group B were higher than those before operation,and the difference was statistically significant(P <0.05).4.There were no significant differences in blood lipids between the two groups after 15 days of PCI.5.There were no significant differences in the statin side effects between the two groups of patients in the A and B groups 15 days after PCI.6.After treatment all subjects were followed for 1 month,there were no significant differences in MACE events between the two groups of patients.Conclusion: 1.Part of PCI can cause different degrees of myocardial damage,causing a transient,varying degrees increase of c Tn I,CK-MB,and further leading to clinical angina and other symptoms.2.Preoperative administration of 20 mg rosuvastatin on the protection of myocardium,inflammatory factor inhibition is more obvious than 10 mg rosuvastatin,and there was no significant increase in recent side effects,indicating that 20 mg rosuvastatin can more inhibit inflammatory response and myocardial damage during PCI.3.Preoperative PCI short-term administration of rosuvastatin(20mg/d)has good safety.4.This study shows that short-term administration of rosuvastatin(20mg/d)can better inhibit myocardial injury and inflammatory response after PCI,can be used in clinical practice.