| Objective: To establish the shock model of traumatic hemorrhagic in desert dry-heat environment in swine,to explore the pathological and physiological characteristics,and the survival rate in the different temperature of desert dry-heat environment,to provide a theoretical basis for further research.Methods: 50 Male Landrace(25kg-35 kg,~9weeks),piglets were randomly divided into normal temperature control group(T: 25±1 ℃,humidity:35 ±5%,n=10),normal temperature of traumatic hemorrhagic shock shock group(T: 25±1 ℃,humidity:35 ±5%,n=10),dry-heat environment control group(T: 40.5±0.5℃,humidity: 10±2%,n=10),dry-heat environment traumatic hemorrhagic shock group(T: 40.5±0.5℃,humidity: 10±2%,n=10),dry-heat II group(T: 41.5±0.5℃,humidity is 10±2%,n=10).According to the groups,all the animals were exposed to their own environment for 3 hours before the experiment at about 0,the experimental animal in the artificial experiment cabin,in their respective environmental exposure for 3 hours,to build a model of hemorrhagic shock trauma,observe and record the changes of vital signs,until the animal died of natural causes.Results: 1.(a)Desert dry-heat environment THS animal survival time was significantly shorter than the normal environment THS group(P<0.01);(b)oxygen reserves of dry-heat environment THS were significantly lower than that in normal environment THS(P<0.05),oxygen consumption and oxygen uptake rate was significantly higher than normal group THS(P<0.05);(c)Dry-heat environment THS HR,CO and CI in was significantly higher than the normal temperature environment TSH group THS;(d)The volume of withdraw blood in dry-heat environment is lower than normal group THS environment;(e)Desert dry-heat environment group exposed to intestinal tissue congestion,spleen weight greater than the normal group.2.(a)Normal THS group survival time was 567 ± 16.9min,dry-heat groupⅠsurvival time was 178 ± 3.6min,Dry-heat group II survival time was 61 ± 2.8min,significant difference between the three groups were compared the survival time of 22 P<0.01;(b)Normal temperature environment at stable at a certain level after THS,decreased from the stable period;The temperature of group I was rise slowly,there was no significant difference between the two adjacent time point temperature;the temperature group II was quickly rose to 42℃ and continue to rise rapidly,until the death,the two adjacent time points temperature significant difference.Conclusion: 1.Desert dry-heat environment THS oxygen consumption,oxygen uptake rate higher than normal temperature THS,blood lactate accumulation occurred early and rapid increase earlier,higher level of metabolism in the body,oxygen demand is more,lead to the damage more earlier and serious in dry-heat THS;High metabolism in dry-heat environment THS lead to CO,HR and CI were higher than the normal group THS;Dry-heat environment due to increased body temperature,heat dissipation mechanism lead to peripheral vascular dilatation,so that the hot dry environment to achieve the same degree of shock when the blood volume is less than normal in group THS,the hemodynamic stability is poor;The desert dry-heatenvironment THS survival time was significantly shorter than that in normal environment,suggesting that desert environment can accelerate the death of the animal THS.2.Desert dry-heat environment Group II survival time was shorter,suggesting that the temperature of in desert environment increases every 1 degrees,can significantly shorten pigs of the traumatic hemorrhagic shock survival time;The speed of temperature rises and the death rate was positively related,temperature increases quickly,shorter survival time,suggesting that desert environment of traumatic hemorrhagic shock treatment process to effectively control the temperature may have important clinical significance. |
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