Studies On The Chemical Constituents Of Horsfieldia Glabra

The dissertation mainly reported chemical constituents of one medicinal plant Horsfieldia glabra.Totally 51 compounds were isolated from this plant,including 7 new compounds.By means of various chromatography methods and spectroscopic evidences,51 compounds were isolated and identified from the trunk and leaves of Horsfieldia glabra.The type of structure are including: 1,3-diarylpropanes,sesquiterpenes,diterpenes,triterpenes,flavans,chalcones,flavanones,flavonoid glycosides,dihydroflavones,arylalkanones,simple aromatic compounds,steroids and ligans.There are(2R,4R)-4′-hydroxy-3′,5′-methyl-6,7-methylenedioxy-4-O-2′-cycloflavan(1),(2R,4R)-4′-hydroxy-3′-methyl-6,7-methylenedioxy-4-O-2′-cycloflavan(2),(-)-catechin(3),(-)-epicatechin(4),(-)-festidinol(5),naringenin(6),(-)-butin(7),(-)-eriodictyol(8),liquiritigenin(9),quercetin(10),morin(11),sulfuretin(12),4,2′-dihydroxy-4′-methoxychalcone(13),(3R)-vestitone(14),quercetin-3-O-β-D-glucoside(15),morin-3-O-α-rhamnopyranoside(16),kaempferol-3-O-α-L-rhamnopyranoside(17),quercetin-3-O-α-L-rhamnopyranoside(18),hemipholin [(+)-6-C-β-D-glucopyranosyl(2S)naringenin](19),1-(2′,4′-dihydroxyphenyl)-3-(2′′-hydroxy-4′′,5′′-methylenedioxyphenyl)-propane(20),1-(2′-hydroxy-4′′,5′′-methoxylphenyl)-3-(3′′,4′′-methylenedioxyphenyl)-propane(21),1-(2′,4′-dihydroxy-3′-methylphenyl)-3-(2′′-hydroxy-4′′,5′′-methylenedioxyphenyl)-propane(22),virolane(23),1-(4′-hydroxy-2′-methoxyphenyl)-3-(4′′-hydroxy-3′′-methoxyphenyl)-propane(24),1-(2′,4′-dihydroxyphenyl)-3-(3′′,4′′-methylenedioxyphenyl)-propane(25),1-(2′,4′-hydroxy-3′,5′-dimethylphenyl)-3-(2′′-hydroxy-4′′,5′′-methylenedioxyphenyl)-propane(26),1-(2′,4′-dihydroxyphenyl)-3-(2′′-methoxy-4′′,5′′-methylenedioxyphenyl)-propane(27),bauhiniasin(28),euonyphenylpropane A(29),horsfiebra A(30),horsfiebra B(31),myristinin G(32),myristicyclin A(33),betulinic acid(34),(-)-(3R)-18-hydroxygeranyllinalool(35),plaunotol(36),4(14)-eudesmene-6α,11-diol(37),(-)-clovane-2,9-diol(38),(-)-caryolane-1,9β-diol(39),vomifoliol(40),(-)-sesamin(41),(-)-kobusin(42),(+)-piperitol(43),(-)-eudesmin(44),demethylpiperitol(45),isocubebin(46),dodecanoylphloroglucinol(47),1-(2,6-dihydroxyphenyl)-4-methyl-4-tridecen-1-one(48),3,6-dihydroxy-2-[1-oxo-9(Z)-octadecenyl]-cyclohex-2-en-1-one(49),3,4-dihydroxybenzoic acid(50),β-sitosterol(51).Compounds 1-2,20,30-32,35 are novel,and compounds 6-8,10-11,14-19,24,26-29,34,36-40,42,44-46 were isolated from the genus Horsfieldia.Except for compound 48,other compounds were separated from Horsfieldia glabra for the first time.Selected compounds 1-2,20,23,31,34-35,42-43,47 were assessed for their in vitro growth inhibitory influences against the different cancer lines(A-549,HL-60,SMMC-7221,SW480 and MCF-7).Compound 31 exhibited certain cytotoxic activitity for five human cancer cells with IC50 values of 18.58 μM,20.76 μM,13.92 μM,18.12 μM,and 12.92 μM,respectively.The other compounds had no activitity in vitro.At last,1,3-diarylpropanes in the plants were reviewed,including chemical constituents and biological activities.