Association Between HRV Of Late Pregnant Women And Pregnancy Outcomes

Objective: To investigate the effect of heart rate variability(HRV)in late pregnant women on pregnancy outcomes.Method: A total of 156 late pregnant women were selected in the prospective research,and were divided into fetal normal group and fetal abnormal group,maternal normal group and maternal abnormal group respectively according to fetal and maternal adverse pregnancy outcomes.Heart rate variability were measured on ambulatory 24-hour ECG,including: time-domain and frequency-domain analysis indexes in all subjects,and pregnancy outcomes were followed up.Improved principal components logistic multivariate regression analysis were used to determine the association between heart rate variability and pregnancy outcomes.Results: In this study,the fetal adverse pregnancy outcome rate was 11.5%;the maternal adverse pregnancy outcome rate 55.1%.(1)In fetal groups,Pearson correlation analysis indicated that the probability of fetal adverse pregnancy outcome decreased with the decreasing of SDNN,RMSSD,LF,HF,while with the increasing of LF/HF.Improved principal components logistic multivariate regression analysis showed that the decrease of SDNN,RMSSD,LF,HF and the increase of LF/HF were the protective factors of fetal normal pregnancy.(2)In maternal groups,Pearson correlation analysis indicated that the probability of maternal adverse pregnancy outcome decreased with the decreasing of SDNN.Improved principal components logistic multivariate regression analysis showed that the decrease of SDNN was the protective factor of maternal normal pregnancy.Conclusion: The probability of adverse pregnancy outcome decreased with the decreasing of the late pregnancy related HRV indexes,whether in fetal groups or in maternal groups.It suggested that the cardiovascular autonomic nerve function changes associated with adverse pregnancy outcomes.The increase of sympathetic nervous activity may be the protective factor of normal pregnancy.