Primary Aldosteronism Associated With Rhabdomyolysis Cases Report And Review Of The Literature

Objective: To investigate the clinical features of primary aldosteronism associate with rhabdomyolysis and to guide the diagnosis and treatment of the disease.Methods: We describe the presentation and symptoms of the two patients in our hospital and review the relevant literature.A thorough literature search disclosed 19 further cases of rhabdomyolysis due to undiagnosed primary aldosteronism.Results: All patients had a history of hypertension,including fatigue,myalgia,hypokalemia and high muscle enzymes,a small number of patients who have abnormal myoglobinuria,acute renal failure and abnormal liver enzyme.Rhabdomyolysis was cured by a large amount of fluid and urine alkalization,all patients were restored to normal blood pressure and normal serum potassium levels after drug or adrenal surgical interventions.Conclusion: For the high risk population of primary aldosteronism early screening can prevent disease progression that causes serious complications such as rhabdomyolysis.For the diagnosis of primary aldosteronism patients with aldosterone adenoma whose serum potassium is lower than 2.0 mmol/L,rhabdomyolysis.should be alerted.Primary aldosteronism patients with rhabdomyolysis,should actively symptomatic treatment and cure the primary disease.