Analysis Of The Pathogens And Bacterial Resistance In 1-3-month-old Infants With Severe Community Acquired Pneumonia

Objective: To investigate the pathogens and bacterial resistance in 1-3 month infants with severe community acquired pneumonia(CAP)in Chongqing.Methods: The pathogens and bacterial resistance in 1-3month inpatients with severe CAP in the ward of Children’s hospital of Chongqing Medical University between January 2014 and December 2015 were studied retrospectively.Results: 1.Bacteria were detected in 268 cases by aspirate culture from deep compartments of nasopharynx among a total of 367 cases,among which there were 209 cases of G-bacteria(78%),59 cases of Gbacteria(22%),while Klebsiella pneumoniae pneumonia,haemophilus parainfluenzae,staphylococcus aureus,Escherichia coli,chlamydia trachomatis and streptococcus pneumonia turned out to be the predominant bacteria.2.Virus were identified in 173 cases,including 147(85%)cases of RSV infection.3.Mixed-infections were found in118(32.2%)cases and mostly bacteria-virus co-infection.4.Drug sensitive test showed that for Staphylococcus aureus there is no obvious change of resistance in the other commonly-used antibiotic except cefoxitin compared with the previous one.As for streptococcus pneumonia,it shows a high resistance in erythromycin and clindamycin compared with the previous one.Klebsiella pneumoniae pneumonia,Hemophilus parainfluenzae and escherichia coli display an overall declining trend in resistance.Conclusion: The pathogens detected are mostly bacteria,especially G-bacilli,in 1-3-month-old in-patients with severe CAP in Chongqing,more attention should be paid to Chlamydia trachomatis in clinical;RSV keeps the major type in virus infection.Mixed-infection is most commonly found as bacteria-virus co-infection.Although the resistant rates to some antibiotics have dropped down by restrict control of use over last years,the overall resistance is still considerable.We suggest an enhanced surveillance over antibiotic administration and proper drug choices according to the antibiotic susceptibility profile to stop the climbing drug resistance.