Predicting Value Of Serum Soluble ST2 For Risk Stratification And Cardiac Function In Patients With Coronary Artery Disease

Objective:To evaluate the predicting value of serum sST2 for risk stratification and cardiac function in patients with coronary artery disease.Methods:We include 64 patients of whom 41 had AMI,15 had unstable angina,8 individuals without significant stenosis on coronary angiography,include 20 outpatients who had Prior MI.Collected the clinical database and biochemical markers.All the recruiters underwent ECG,UCG and ECT,finished the CAG to evaluate the coronary artery pathology.Serum levels of ST2 were measured by ELISA.Results:sST2 levels were significantly increased in patients with AMI as compared to patients with unstable angina and Prior MI as well as non-CAD(P<0.001),The level of sST2 were not significantly between unstable angina and Prior MI(P=0.997).A significant negative correlation between sST2 levels and LVEF were found(P=0.029),there was no relationship between sST2 levels and the lesion of the infarct myocardial as well as the numbers of the occlusion coronary artery(P=0.698,0.782).It has no relationship with the emergency thrombolytic therapy and PCI(P=0.14).sST2 level is closely related to the cardiac function,but in ROC analysis,the area under the curve for sST2 was no different from that for NT-ProBNP,an AUC of 0.782 for sST2(95%CI0.684-0.880),an AUC of 0.798 for NT-ProBNP(95%CI0.708-0.893),correlation analysis showed r=0.388,P <0.001.Conclusion:The sST2 has the value of screening for patients who are in high risk of coronary artery disease,It also help for the risk stratification and predicting the activity of disease in these patients;The level of sST2 is negative to the cardiac function,but there are no statistical significant difference between sST2 and NT-ProBNP.