The Value Of PTX3 Level In Bronchoalveolar Lavage Fluid For Early Diagnosis Of Lung Lump

Objective: To investigate the diagnostic value of the detection of PTX3 in bronchoalveolar lavage fluid(BALF)for the identification of benign and malignant lung lump.Methods: A total of 87 patients with bronchoscopy identified by chest CT scan were divided into two groups: the lung cancer group(n = 53)and the benign lung lesion group(n = 34).The patients were treated with enzyme-linked immunosorbent assay(ELISA)to detect PTX3 level in bronchoalveolar lavage fluid.Research result:(1)The level of PTX3 in lung cancer group is higher than that in benign lung lesions group,and the difference is statistically significant(4.0 ± 0.4ng / ml vs 2.7 ± 0.5ng / ml,P = 0.0274).(2)The level of PTX3 in BALF in squamous carcinoma group is significantly higher than that in benign lung lesions(4.5 ± 0.4ng / ml vs 2.7 ± 0.5ng / ml,P = 0.0062).(3)There is no significant difference for PTX3 level between adenocarcinoma subgroup,small cell carcinoma subgroup and benign lung lesion group(3.4 ±0.6ng/ml vs 2.7±0.5ng/ml,P=0.4332;1.9 ±0.7ng/ml vs 2.7±0.5ng/ml,P=0.4964).(4)The best cutoff value of PTX3 in bronchoalveolar lavage fluid is 0.2623 ng / ml,the sensitivity of diagnosis of lung cancer is 60.38% and the specificity is 55.88%.(5)The optimal cutoff value of PTX3 in bronchoalveolar lavage fluid to diagnose lung squamous cell carcinoma is 2.195 ng / ml.The sensitivity of diagnosis of lung squamous cell carcinoma is 80.00% and the specificity is 67.65%.Conclusion: The detection of PTX3 in BALF by enzyme-linked immunosorbent assay(ELISA)can be used as an adjunct to the identification of benign and malignant lung cancer.The method shows its significance for distinguishing squamous cell carcinoma,adenocarcinoma,small cell carcinoma and improving the identification of lung cancer,and may have a certain clinical value.