Analysis On The Relationship Between The Components Of Urinary Stone And Metabolic Syndrome

Introduction:Urinary calculus is one of the most common diseases of urology.With the clinical characteristics of high incidence and high recurrence rate,urolithiasis has become an important problem in modern medicine,which adds a heavy burden to human health and national health expenditure.Therefore,the prevention of recurrence of urinary calculus has become the focus of urologists.In recent years,with the deepening research on the etiology of urinary calculus,the risk factors related with metabolism are being paid more and more attention by urologists.Metabolic syndrome(MS)is defined as a clinical syndrome with the main manifestation of obesity,hypertension,hyperglycemia and dyslipidemia.Epidemiological studies in recent years found that MS and its components such as obesity,hypertension and diabetes have a significant correlation with the incidence of urolithiasis,which provided a reliable clinical basis that one can change his/her lifestyle to achieve the purpose of prevention of urolithiasis.The researchers are now looking forward to finding the ways to interfere in occurrence and development of the disease.Objective: To investigate the relationship between urinary calculus and metabolic syndrome by retrospective case analysis,and to provide a reference for clinical prevention and recurrence of urinary calculus.Methods: The clinical data of 314 patients who were treated with urinary calculi from September 2015 to December 2016 in the First Affiliated Hospital of Soochow University were retrospectively analyzed.The data includes 212 male cases and 102 female cases,aging from 17 to 86 years old.The average age is(52.74 ± 14.53)years old.According to the diagnostic criteria of MS,the patients are divided into two groups.The MS group includes 63 patients,37 males and 26 females,with an average age of 56.98 ± 10.4 years.There are 251 cases in non-MS group,including 175 males and 76 females,with an average age of(51.68 ± 15.22)years old.Infrared spectral analysis was used to analyze the components of urinary calculus.SPSS(version 20.0)was used for statistical analysis,and the differences of the two groups were compared.Results: There are 16 cases(25.4%)of uric acid stones in MS group,the proportion of which is significantly higher than that in non-MS group(9.6%),and the difference is statistically significant(P <0.05).MS mainly includes four kinds of metabolic diseases,namely hyperglycemia,hypertension,dyslipidemia and obesity.Among the patients included,88 cases are suffering from one metabolic disease,including 11 cases(12.5%)of uric acid stones;90 cases are suffering from two kinds of metabolic diseases,including 13 cases(14.4%)of uric acid stones.There are 50 cases having three kinds of metabolic diseases,involving 12 cases of uric acid stones(24.0%);while 13 cases are suffering from four kinds of metabolic diseases,of which 4 cases of uric acid stones(30.8%)are involved.Multivariate logistic regression analysis showed that the OR value of hyperglycemia is 2.53(95%CI:1.253—5.102,P = 0.010)after adjusting for sex and age.Conclusion: 1.The proportion of uric acid stones in MS patients is significantly higher than that of patients without MS;And with the increase in components of MS,the risk of uric acid stones will increase;2.MS is related to the formation of uric acid stone;3.Compared with other components of MS,hyperglycemia is the most important risk factor for uric acid stones.