The Study Of Early-prevention Strategy Of Breast Cancer Based On Menstruation Condition And Its Influence Factors

Objective To systematically review the association between menstrual condition and the risk of breast cancer by a meta-analysis and to understand irregular menstruation status and its influencing factors among female college students by a sampling survey.Thus to screen the high-risk population of breast cancer and to provide a scientific guidline for preventing disease of breast cancer and irregular menstruation.Method(1)Such databases as CNKI,Wanfang,VIP,Pub Med,EMbase,Science Direct and The Cochrane Library(Issue 4,2016),were electronically searched from the inception to December 31 th,2016to collect studies about the correlation between menstrual condition and breast cancer.Two reviewers independently screened literature,extracted data and assessed the quality of included studies.The meta-analysis was performed using Stata12.0 software.Cochrane’s Q and I2 statistics were used to evaluate heterogeneity among studies,subgroup analysis and sensitivity analysis were used to explore the heterogeneity sources.Publication bias was calculated by Begg rank correlation test and Egger linear regression test.(2)Anonymous questionnaire survey was conducted among female college students in Hengyang city by cluster random sampling method based on class.Two researchers independentlyinput survey results by using Epi Data3.1,sort and analyze data by using SPSS18.0.Results(1)Eighty-three studies involving 48 811 breast canc-er patients and 57 268 controls were finally included.The results of meta-analysis showed that the overall OR(95%CI)between the age at menarche ≤13,irregular menstruation and breast cancer were separately 1.18(1.12~1.24),1.98(1.62~2.41).Further subgroup analysis showed that the degree of correlation between age at menar-c he ≤13 and breast cancer was community exceeding hospital control,irregular menstruation and breast cancer was northerners exceeding southerners.The overall OR(95%CI)between history of dysmenorrhea and breast cancer in community control,southerners and after removing small-sampled studies were separately 1.50(1.29~1.75),1.72(1.23~2.41),1.47(1.36~1.59).(2)The average menarche age among female college students in Hengyang was(13.18±1.25)year.The rate of irregular menstruation was 47.51%,influencing factors i nclude the family history of irregular menstruation(OR=3.99,95%C I=1.97~8.06),poor sleep quality(OR=1.34,95%CI=1.12~1.60),lat e sleep time(OR=1.26,95%CI=1.03~1.54),spicy diet(OR=1.50,95%CI=1.14~1.97),using antiperspirant(OR=1.45,95%CI=1.11~1.91).The rate of menstrual symptom was 52.12%,influencing factors include history of benign breast disease(OR=2.67,95%CI=1.22~5.89),the history of mother’s dysmenorrhea(OR=1.92,95%CI=1.41~2.61),poor sleep quality(OR=1.41,95%CI=1.19~1.69),using skinwhitenin care product(OR=1.34,95%CI=1.01~1.76),using nail pol-ish(OR=1.45,95%CI=1.06~1.98),depression(OR=1.47,95%CI=1.09~1.98),tired of learning(OR=1.45,95%CI=1.13~1.85),drinkingjuice(OR=0.63,95%CI=0.48~0.82).Conclusion(1)Early age at menarche,irregular menstruation and history of dysmenorrhea probably are risk factors of breast cancer.Due to the limitation of the number of included studies,the relati onship bteween cycle time≥30 days,period of time>7days and breas t cancer are not found.(2)The incidence rates of irregular menstr uation and menstrual symptom among female college students in He ngyang are high,and it’s influencing factors are complicated.Famil y history of irregular menstruation,poor sleep quality,late sleep ti me,spicy diet,using antiperspirant are risk factors of irregular me nstruation;history of benign breast disease,the history of mother’s dysmenorrhea,poor sleep quality,using skin-whitenin care product,using nail polish,depression,tired of learning are risk factors of m enstrual symptom,drinking juice is protective factor of menstrual sy mptom.On one hand,We should strengthen treatment of patients of irregular menstruation or menstrual symptom,on the other hand,w e should reinforce the related prevention and intervention to reach t he effect of early preventing breast cancer.