Analysis Of The Etiology And Bone Age With Short Stature Children

Objective:To investigate the etiology of short stature.To analyze bone age status of children with short stature.Methods:1.This is a retrospective study of children with short stature admitted to the department of endocrinology in Nanjing Children’s Hospital.2.The data were collected from 2132 physical examination results of patients between the year of 2009 and 2014.Results:1.Among the 2132 patients,1333 were males and 799 were females.Of these,324 cases(15.2%)were diagnosed as complete gro"wth hormone deficiency(CGHD),780 cases(36.59%)were partial growth hormone deficiency(PGHD),27cases(1.27%)were multiple pituitary hormone deficiency,13 cases(1.64%)were hypothyroidism,893 cases(41.89%)were idiopathic short stature(ISS),40 cases(1.88%)were chromosomal disorders.2.Data analysis was done using ANOVA method.Significant difference in the patient’s age and bone age was found using t test(P<0.05).Significant differences in Aage were found between etiological categories using ANOVA(P=0.000).Aage was significantly and negatively associated with peak GH using Pearson’s correlation.Conclusions:This study shows the most common cause of short stature is GHD(>50%).Bone age of children with short stature is delayed,and its severity was significantly and negatively associated with peak GH.Objective:1.To investigate the effects of growth delay in patients with Turner syndrome(TS)2.To analyze factors that influence growth delay in patients with Turner Syndrome(TS).Methods:1.The total of 34 patients diagnosed with TS in the Endocrinology department of Nanjing Medical University Affiliated Children’s Hospital between February 2009 and August 2014 were involved in this study.2.All patients presented with the short stature or delayed growth,and diagnosis was confirmed with chromosome karyotypes analysis.This study purposed to analyze the relationship between the patients karyotypes and growth delay.Results:1.From the 34 cases collected,one patient had the height of-1.1 SDS,while the other 33 patients had the height less than-2 SDS.From the assessment of the karyotypes,19 patients had karyotypes of non-mosaic 45,X,and 15 patients had karyotypes of mosaic 45,X with 45X/46,X,i(Xq),as the most frequent mosaic cell lines.The results of growth hormone(GH)stimulation test showed there were 7 patients with GH peak level of<5ng/ml,15 with GH peak level between 5ng/ml to 10ng/ml,and 12 patients with GH peak level>10ng/ml.2.Using the linear regression analysis,height SDS and age were dependent variable,age and weight SDS were significant predictors of height SDS(P = 0.002;P =0.000).Bone age,weight SDS,body mass index(BMI),peak GH,IGF1 level,estrogen(E2),Luteinizing Hormone(LH),Follicle-Stimulating Hormone(FSH)levels are the independent variables(P>0.05).Based on karyotypes,patients were divided into two groups,non-mosaic 45,X and mosaic 45,X.To comparison of the two karyotypes,there was no significant correlation between karyotype categories and height SDS(P=0.281).Conclusion:Short stature was the most common clinical presentation in patients with TS,there was a tendency that increased age lead to decreased height SDS.Patients with TS had GH deficiencies based on the GH stimulation tests,but there was no significant correlation between peak GH and height SDS.In this study,45,X was the most karyotype in patients with TS.There was no significant correlation between karyotype categories(mosaic and non-mosaic)and height SDS.