Research On The Integrated Process Of Original Processing And Processing Of Phytolacca Radix

In this paper,we got the scientific research program of the national Chinese medicine industry:30 kinds of key technical specifications for the integration of processing area and processing production of Chinese herbal medicine,(201507002).Chinese herbal medicine is one of the basic forms of clinical medicine in traditional Chinese medicine.The quality of Chinese herbal medicine has a direct impact on the clinical effect of traditional Chinese medicine.At present,the disintegration of processing and original processing of traditional Chinese medicine has seriously affected the production efficiency and product quality of Chinese herbal medicine.The key technical specifications for the integrated processing and processing of Chinese herbal pieces will provide technical support for improving the production efficiency and ensuring the quality of Chinese herbal pieces.Phytolacca is the radix of Phytolacca acinosa Roxb.and Phytolacca Americana L.,production process of Phytolacca is:"autumn September to spring March excavation,removal of fibrous roots and sediment,sliced,dried or dried." The production process of Phytolacca pieces is:"remove impurities,wash,moisten,cut thick slices,dry." The topic for the process and processing of Phytolacca pieces,repeated processing operations are not standardized,run system to soften the loss of active ingredients,manpower consumption and other issues.1.Research on standardization of traditional processing technology of Phytolaccae RadixTaking the appearance,moisture content,soluble extract and esculentoside A as index,the single factor method was applied to optimize the processing parameters of Phytolacca pieces.From the traditional processing technology optimization for taking Phytolacca pieces:fresh Phytolaccae Radix,into the drum type washing machine and wash away the mud and impurities removal of non medicinal parts of roots,stem base with saws and knives,50? low temperature drying(1?2 days),drying the raw materials of Phytolaccae Radix.For 2?3 hours,drainage,covered with wet sacks run midway through the system,timely and appropriate spray,moistening(1?2 days)until soft,cut 5 mm thickness,thickness of 15?20 mm,hot air circulation oven drying at 70? for 12?15 hours,which is 4 mm thick slices of phytolacca.It takes about 96 hours(about 4 days)to use the whole traditional processing method to prepare the Phytolacca pieces.2.Study on the integrated process of processing and original processing of Phytolaccae RadixTaking the appearance,moisture content,water-soluble extract and esculentoside A content as index,a single factor method was applied to establish the integrated processing and processing technology of Phytolacca pieces,and the integrated processing parameters of processing area and processing area of Phytolacca pieces were optimized.From the origin processing and integration process to establish and optimize the processing for fresh Phytolaccae Radix,into the drum type washing machine and wash away the mud and impurities removal of roots,stem and other non medicinal parts,cutting 6 mm thickness,paving thickness of 18?20 mm,the hot air circulation oven drying at 75?for about 16?17h,which is 4 mm thick slices of Phytolacca pieces.The processing time of the whole place processing and processing is about 24 hours.So the processing efficiency of the processing area is faster than that of the fresh cut.The production efficiency is much higher than that of the traditional drying,re drying and drying.3.Pilot production of two kinds of processing methods for Phytolaccae RadixBased on the traditional processing technology of Phytolacca pieces on the laboratory selection,combined with the actual situation of Chinese medicines production enterprise,production test in Nanjing Haichang Chinese medicines limited company GMP certification of Chinese herbal medicine production workshop,established the trial production technology of processing Phytolacca pieces,capable of guaranteeing the quality of traditional processing stability,excellent pieces of phytolacca.Three batches of Phytolacca pieces were prepared in each batch of 50kg fresh Phytolaccae Radix,and the traditional processing technology of Phytolacca pieces(SOP)was established.In the production process of processing Phytolacca pieces:fresh Phytolaccae Radix,into the drum type washing machine and wash away the mud and impurities removal of roots,stem and other non medicinal parts,50? low temperature drying(1?2 days),to dry the raw materials of Phytolaccae Radix.For 2?3 hours,a pool of water drainage,covered with wet sacks run midway through the system,timely and appropriate spray,moistening(1?2 days)until soft,cut 5 mm thickness,paving thickness of 15?20 mm,hot air circulation oven drying at 70? for 8?10 hours,which is 4 mm thick slices of phytolacca.lt takes about 96 hours(about 4 days)to use the whole traditional processing method to prepare the Phytolacca pieces.On the basis of Phytolaccae Radix origin processing and integrated processing technology,processing and optimization of the laboratory was established,combined with the actual situation of Chinese medicines production enterprise,,production test in Nanjing Haichang Chinese medicines limited company GMP certification of Chinese herbal medicine production workshop,etermine and improve the technology of Phytolaccae Radix origin processing and large-scale production processing integration.The technology is suitable for large-scale,industrial production,and can ensure the quality of the integrated processing and processing of the production and processing of Phytolacca pieces.Three batches of Phytolacca pieces were prepared for each batch of 50kg fresh Phytolaccae Radix,and an integrated processing and processing technology of Phytolacca pieces(SOP)was established.The integration of Phytolacca pieces origin processing and production process for processing test:fresh Phytolaccae Radix,into the drum type washing machine and wash away the mud and impurities removal of roots,stem and other non medicinal parts,cutting 6 mm thickness,paving thickness of 18?20 mm,the hot air circulation oven drying at 75? for about 10?12h,which is 4 mm thick slices of phytolacca.The processing time of the whole place processing and processing is about 16 hours.So the processing efficiency of the processing area is faster than that of the fresh cut.The production efficiency is much higher than that of the traditional drying,re drying and drying.4.Comparison of the quality of processing and processing and traditional processing of traditional processed pieces of PhytolaccaThe integration of the same batch of homemade origin processing and processing and processing of the traditional pieces of Phytolacca ten groups between the same batch of two kinds of processing methods of production of Phytolacca pieces for appearance,moisture content,water soluble extractives,esculentoside A comparison of the content,observing the appearance of characters,two kinds of processing technology of production Phytolacca pieces of bright color,compass obvious grain appearance traits,are in line with the description of the 2015 edition of Chinese Pharmacopoeia under Phytolacca character;water content,two kinds of production process produced pieces of water were kept in Phytolacca pieces a better range(8%?12%);water soluble extracts,origin processing and the integration of processing pieces of water-soluble extracts than processing Phytolacca pieces with an average high of 20%pieces of Phytolacca,that traditional processing pieces in softening water embellish Phytolacca process extracts damage lost;comparison of esculentoside A content,traditional processing pieces esculentoside A content is the origin processing and processing integration Phytolacca pieces was 43%higher,the results and easy to assume that traditional processing pieces run for Phytolacca softening of esculentoside A content will be lost.It is necessary to further study the reasons for the increase of the content of esculentoside A in the traditional processed Phytolacca pieces.In the process of softening processing Phytolacca pieces run in esculentoside A abnormal increase,which is consistent with traditional processing than the origin processing and processing integration of Phytolacca pieces of esculentoside A increased the content of the results,reasons of traditional processing than the origin processing and processing integration of Phytolacca pieces of esculentoside A high content of traditional processing may be softening transformation components run in the process,the transformation of the argument of Phytolacca pieces ELSD-HPLC and UHPLC-Q-TOF-MS/MS analysis in processing Phytolacca pieces,elevated traditional processing pieces of Phytolacca esculentoside A content is due to raw material drying process of Phytolaccae Radix run in Phytolacca pieces bond hydrolysis of esculentoside H,esculentoside H and esculentoside A similar structure.Esculentoside H also has some pharmacological effects and clinical efficacy,so in Phytolacca pieces,the quality of the Phytolacca pieces can not be evaluated in esculentoside A.The rat gastric lavage in rats,0?5h urine volume index,diuretic effect comparison of two kinds of processed Phytolacca pieces of rat,diuretic effect,origin processing and processing integration of Phytolacca pieces high dose group and high dose group of traditional processing of Phytolacca pieces compared urine volume increased significantly,with statistical difference,The integration of processing and processing of Phytolacca pieces producing area is stronger than that of traditional processing of Phytolacca pieces.In view of its strong fiber,hard texture,large shape and high moisture content,Phytolaccae Radix is not easy to dry and become the original medicinal material of Phytolaccae Radix.After drying,softening and moistening is time-consuming and laborious,and it is not easy to soften.The technology of producing and processing in producing area is especially suitable.Compared with the traditional processing technology,no need to spend a long time will be a long time consuming dried herbs,dried herbs will soften after slicing,can save a lot of manpower,material and financial resources consumption,production processing and processing technology of Phytolacca pieces is more suitable for large-scale,industrial production and processing and the origin of Phytolacca pieces;preparation the integration process of Phytolacca pieces of water-soluble extracts than traditional processing pieces and The diuresis effect of rats is also stronger than that of traditional processed Phytolacca pieces,processing technology and processing integration of Phytolacca origin processing is feasible.5.production process(SOP)and quality standard of Phytolacca piecesThe traditional processing of homemade pieces and the market to collect the origin of Phytolacca pieces of ten groups to observe their characters,determination of the moisture content,total ash content,acid insoluble ash content,water soluble extract and the content of esculentoside A,to determine the average value of ±20%to limit,combined with processing Phylolacca pieces optimization of the machining technology,making processing Phylolacca pieces production process(SOP)and quality standard research.Take the origin processing and processing integration of homemade pieces and the market to collect the origin of Phytolacca pieces of ten groups to observe their characters,determination of the moisture content,total ash content,acid insoluble ash content,water soluble extract and esculentoside A content,to determine the average value of ±20%to limit,combined with the origin processing and processing integration process to establish and optimize the formulation of Phylolacca pieces origin processing and processing technology of integrated production(SOP)and quality standards.