| Objective: To investigate the correlation between the level of exhaled carbon monoxide(CO)in children with asthma and the level of control test in children with asthma and its potential influencing factors.Methods: 185 pediatric asthma patients from 2016 to 2018 were selected by random sampling method,and the diagnostic criteria for children bronchial asthma were taken as the diagnostic criteria of the 2016 edition of the National Paediatric asthma prevention and treatment initiative update.A total of 158 children with asthma were selected as subjects to collect the measured values of the child C-ACT.According to the C-ACT score,185 children with asthma were divided into 58 mild cases,62 moderate cases,and 60 severe cases.30 healthy children were selected as control groups;By sex,there are 100 male children and 85 female children.The levels of eCO and FeNO in all children were measured as indicators of airway inflammation and oxidative stress.The sensitivity range to CO level was 0.1-500 ppm by electrochemical CO measuring instrument.Fe NO was detected with a chemiluminescence analyzer,and the sensitivity range to NO levels was 1-5000 ppb.Pulmonary function was measured using the German Jeager Master Screen-IOS automatic lung function instrument.All subjects were repeatedly measured 3 times,and the best values such as FEV1,FVC,and PEF were taken.With regard to the treatment,In this study,the children were treated with inhaled corticosteroids alone,leukotriene receptor antagonists alone,combined with inhaled corticosteroids +inhaled β2 agonists,inhaled corticosteroids + leukotriene receptor antagonists or inhaled corticosteroids + inhaled β2 agonists.+ White triene receptor antagonist.Results: In this study,185 children admitted to the study were grouped according to mild,moderate,and severe conditions.Although there were differences in the severity of the condition,there was no difference in the proportion of the use of concentrated methods in the treatment.It can be seen that the clinical treatment principles were consistent.Using the X2 test,there was a significant difference in thelevel of eCO in each group of asthmatic children and the control group(p 0.05),and there was also a significant difference in the level of eCO between children with different levels of asthma(p 0.05).According to the male and female groups,the eCO level of men and women has the same trend as the female group,and there is no significant difference.Statistics on the levels of exhaled carbon monoxide,exhaled nitric oxide,FEV1,FEF,and FVC,and the main risk factors affecting the control level of asthma were eCO.Conclusion: through the analysis and discussion of this study,it is suggested that the exhaled carbon monoxide level and detection have a certain clinical significance in the control of asthma children’s condition.With the increase of eCO level,the lung function of asthma children is gradually reduced,and it is also reflected in the control of asthma.level,The performance is gradually reduced by the C-ACT score;And when the level of eCO is very high,it can be seen that the level of Fe NO expression in boys has also increased significantly,suggesting that airway inflammation is more serious;In addition,the increase of eCO is one of the independent risk factors in combination with the potential influencing factors in the internal and external environment and jointly affecting the concurrent control status of children with asthma. |
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