Effect Of Short-acting Gonadotropin Releasing Hormone Agonist Pituitary Down-regulation Time On IVF-ET Pregnancy Outcomes

Objective:To investigate the effect of increasing the pituitary down-regulation time in the short-acting GnRH-a long regimen on the pregnancy outcome of in vitro fertilization-embryo transfer,and to find the optimal pituitary down-regulation time.Methods:We retrospectively analyzed the infertility patients who received in vitro fertilization and embryo transfer for fertility treatment at the Reproductive Fertility Center of the First Affiliated Hospital of Xinjiang Medical University from December 2012 to July 2017.Both of them used short-term corpus luteum GnRH-A pituitary down-regulation program,a total of 89 IVF cycle data,according to the time before the administration of gonadotropin pituitary downgrading divided into three groups: A group: pituitary down regulation time≤14d,B group: 14d<pituitary down regulating time<21d;group C: pituitary down-regulation time≥21d.The general conditions of the three groups were compared: baseline female endocrine hormone levels,pituitary down regulation,Gn use,HCG day female endocrine hormone levels and endometrial thickness,laboratory indicators,pregnancy outcomes and complications.Results:There was no significant difference in the general conditions and basic female endocrine hormones between the three groups(P>0.05).There was a statistically significant difference in LH levels between the three groups on the initiation date of Gn(P<0.05).The A group was higher than the other two groups,but there was no statistical difference between the groups(P>0.05).There were no statistically significant differences between the three groups in terms of treatment outcomes,pregnancy outcomes,and complications(P>0.05).Conclusion: This study suggests that pituitary down-regulation time has a certain effect on pregnancy outcomes in the short-acting GnRH-a long-term regimen of controlled ovulation induction,with an appropriate increase in pituitary down-regulation time(≥21d)and a tendency to increase IVF-ET pregnancy rates.However,due to the small sample size,no conclusion can be drawn that increasing pituitary down-regulation time affects IVF-ET pregnancy outcomes.