Clinicopathologic Features Of Papillary Thyroid Carcinoma With Coexistent Chronic Lymphocytic Thyroiditis

Objective:To investigate clinical and pathological features of patients with papillary thyroid carcinoma(PTC)with coexistent chronic lymphocytic thyroiditis(CLT).Methods:The clinicopathologic data of 756 cases of PTC were collected from January2014 to January 2017 in the First Affiliated Hospital,Xinjiang Medical University were collected.The patients were designed into observational group(PTC with coexistent CLT,n=194)and control group(simple PTC,n=562)according to whether CLT was diagnosed by pathology,then the clinical data,ultrasonic features,thyroid function,and pathological features in these two groups were compared.Results:The proportions of the female patients and multifocal carcinomas in the observational group were significantly higher than those in the control group(P<0.05).The levels of the serum thyroid autoimmune antibodies(thyroglobulin antibody and thyroid peroxidase antibody)and the serum thyroid stimulating hormone were increased in the observational group as compared with the control group(P<0.05).There were no significant differences in the preoperative ultrasound,tumor diameter,thyroid capsule invasion,central lymph node metastasis,and TNM stage in these two groups(P>0.05).The results of the multivariate analysis showed that the female,serum thyroid autoimmune antibodies,and the multifocal carcinoma were the independent predictive factors of PTC with CLT(P<0.05).Conclusions:There might be a certain correlation between PTC and CLT,PTC with coexistent CLT is more common in female patient and with multifocal carcinoma.With coexistent CLT does not increase invasion of PTC.This may be associated with limit of CLT to development of PTC nodules.It is speculated that CLT may be a protective factor of PTC.The higher serumTG-Ab and TPO-Ab levels of the observational group indicate that CLT may be one of the risk factors of PTC.