The Clinic Pathological Analysis And Relative Agents Study For The Papillary Thyroid Carcinoma And Lymphocytic Thyroiditis

Objective: To study the clinic pathological characteristics and the significance of the expression for CK19, RET, Survivin protein in lymphocytic thyroiditis (LT), thyroid papillary carcinoma(PTC) and LT with PTC. Methods: The clinic-pathological material of 306 cases LT,190 cases PTC and 76 cases LT with PTC from 2004 to 2006 in Tumor Hospital Affiliated to Xinjiang Medical University were analysed, including age, sex, nation, lymph-node metastases and the macroscopic and microscopic characteristics. Meanwhile, CK19, RET and Survivin protein were detected in 26 cases of PTC, 26 cases of LT, 28 cases of LT with PTC and 15 cases of normal thyroid tissue by immunohistochemistry stain. Results: 1) Clinic-pathological analysis: In 306 cases LT, 190 cases PTC and 76 cases LT with PTC, the mean age were 45.2, 43.3, 39.9 years old respectively. The incidence in women were more than that in men. LT with PTC accounted for 19.9% in LT , 28.6% in PTC. In 76 cases LT with PTC, 18 cases were found lymph-node metastases (23.7%) lower than simple PTC(35.8%). 2)Immunohistochemistry study: The positive rates for CK19, RET, Survivin in LT, PTC and LT with PTC were higher than normal thyroid tissue, there were statistical differences (P<0.05). There weren't statistical differences in the positive rates for CK19, RET,Survivin comparing carcinoma with paracarcinoma lymphocytic thyroiditis tissue in LT with PTC group (P>0.05). The positive rate for CK19, RET, Survivin in paracarcinoma lymphocytic thyroiditis tissue of LT with PTC were higher than those in simple LT ,there were statistical difference for CK19 and Survivin (P<0.05). The lymph-node metastases group of the simple PTC, the positive rate for Survivin was higher than that without lymph-node metastases group, there was statistical difference (P<0.05). The LT with PTC group was same. The positive rate for CK19 in no lymph-node metastases group, simple PTC (100%) was higher than LT with PTC (73.3%), the difference showed statistical meaning (P<0.05). Conclusions: 1) The incidence of LT, PTC and LT with PTC was higher in women than in men, mean age was about 40 years old. 2) LT with PTC account for 19.9% of LT. There were similar expression for CK19, RET, Survivin in LT with PTC group and PTC group. The results showed LT was closely related with PTC. It may be a kind precarcinoma condition, should be pay more attention on it. 3) The incidence of lymph-node metastases of LT with PTC group was lower than that in simple PTC group, therefore, the prognosis of LT with PTC was better than simple PTC. It was proved again in detecting of CK19. 4) There was positive relationship between the expression of Survivin and lymph-node metastases in PTC and LT with PTC. So detecting Survivin in PTC and LT with PTC maybe useful for the assessment of prognosis. 5) Survivin was strong positive expression in follicular of acidophilic change in LT, the results showed these kind of cells were proliferative activity, weren't apoptosis cells.