Study On Brain Activation Pattern Changes Of Plateau Population By Rest State-functional Magnetic Resonance Imaging

Objective 1.With the rapid development of economy and society in plateau area,the influence of plateau on human body has aroused people’s concern.And the brain is very sensitive to hypoxia,long-term hypoxia can affect brain function and brain structure.In this study,the 3.0T hyper-high Blood-oxygen level dependent fMRI resonance imaging technique was used to to explore the effect of plateau chronic hypoxia on the brain function of plateau normal population,and to provide a noninvasive and repeatable imaging basis for studying the effect of hypoxia on plateau residents ’ nervous system.2.Using diffusion tensor imaging technique,the changes of brain microstructure in patients with high altitude and altitude polycythemia,hapc were studied from the perspective of imaging.Also understand whether there is a correlation with hemoglobin.Methods 1.Collection of Habitat Plateau Healthy Tibetan(experimental group)and age,sex,education years,altitude and the hand situation of the first into the plateau six months(control group)of healthy Han volunteers each of 30 cases,the whole brain routine MRI flat sweep+DWI scan,except for a case of Tibetans with multiple chronic ischemic foci ruled out,No organic lesions were found in the brain of the remaining subjects.Siemens Skyra 3.0T magnetic resonance is used tocollect BOLD data.Using local consistency ReHo/FALL/fALFF/VMHC/FC are used to deal with BOLD data.The two groups of data are statistically analyzed using a voxel based two sample t test,and the activated clumps are extracted and analyzed with the cognitive function MMSE score.2.To collect and analyze 13 cases of Tibetan patients(experimental group)with clinically diagnosed in high altitude polycy-themia,13 cases of sex,age,educational level,hand-holding situation and living altitude matched normal healthy Tibetan Volunteers(control group),using Siemens Skyra 3.0T Magnetic resonance to collect DTI data,The ROI of the same part was selected in two groups of images,including the bilateral frontal lobe,the forelimbs of the inner capsule,the hind limb of the inner capsule,the dorsal thalamus,the half oval center and the knee and the pressure part of the corpus callosum.The average apparent diffusion coefficient(ADC value)and anisotropy fraction(FA)of the two groups were observed,and there was no difference between the two groups,and the data of the experimental group were correlated with the hemoglobin.Results 1.In the resting state,the ALFF in the control group showed a local decrease compared with the experimental group,indicating that the neurons in these brain regions were inhibited and the metabolism was weak,and the difference was statistically significant.(P<0.001,cluster>5,TFCE correction).2.In the rest state,the contrast group showed a local symmetry enhancement compared with the mirror homotopy connection(VMHC)of the cerebral hemisphere in the experimental group.It showed that the functional connections were enhanced on both sides of the frontal brain region,and the difference was statistically significant(P < 0.001,cluster> 5,TFCE correction).3.The correlation analysis between the two groups of ALFF and VMCH values and the cognitive function MMSE score was analyzed.There was no correlation between the two groups of ALFF and VMHC values and the cognitive function MMSE score(P > 0.05).4.There was no local elevation or partial decrease in ReHo/fALFF and FC in the control group compared with the experimental group.5.The FA value of the left posterior limb of the internal capsule,the center of bilateral oval circle and the compression part of the corpus callosum in the HAPC group was lower than that of the control group(P< 0.05),and the ADC value of the anterior limb of bilateral internal capsule and the pressure part of the corpus callosum was lower than that of the control group(P < 0.05).6.The ADC value of the anterior limb of the left internal capsule was positively correlated with the cognitive function MMSE score,and the ADC value of the left thalamus was positively correlated withhemoglobin.Conslusions 1.There are differences in FALL and VMHC between healthy Tibetan and healthy Han nationality,which may be related to brain damage by the unique hypoxia and hypoxia environment in the plateau.2.There were differences in brain apparent diffusivity and anisotropy fraction ROI between Tibetan and healthy Tibetan volunteers at high altitude,indicating differences in white matter between the two groups,which may be related to the adaptability of plateau low pressure,hypoxic environment and the adaptability of plateau residents to the environment.3.There was a correlation between ADC values in some ROI white matter regions and HBV and MMSE scores in patients with high altitude polycythemia.