The Relationship Between Subclinical Hypothyroidism And Metabolic Syndrome In Middle-aged And Elderly Individuals

Objective To investigate the prevalence of subclinical hypothyroidism(SCH)in middle and elderly individuals and explore the relationship between it with metabolic syndrome(MS).Methods Baseline data from the "REACTION study" in Gansu Province were used in this study,and we extracted relevant data from questionnaire surveys,physical examinations,and laboratory tests,and a total of 9381 eligible subjects were included in the study.The five components of MS were defined as central obesity,hypertriglyceridemia,low HDL-C hyperlipidemia,elevated blood pressure and elevated blood glucose.According to the status of the thyroid function,research objects were divided into normal group and SCH group,SCH group was divided into mild SCH and severe SCH group according to the level of thyroid stimulating hormone(TSH),and compared the prevalence of MS and its components among the 3 groups.The partial correlation analysis was used to analyze the correlations between the level of TSH and the diagnostic components of MS.Binary logistic regression analysis was further used to explore the relationships between SCH and MS and their components.Results(1)The prevalence of SCH is 32.1%;(2)The prevalence of MS was 39.4%,and it in males was higher than that in females(48.8% VS 35.7%,P<0.05),what's more,the prevalence rate was increased with age and was highest among people aged 60-69.(3)The prevalence of MS,hypertriglyceridemia,low HDL-C hyperlipidemia,and elevated blood pressure in patients with severe SCH were higher than those in normal control group(all P<0.05).(4)The TSH levels in MS group were higher than those in non-metabolic syndrome(NMS)group(3.76±2.13uIU/m L VS3.68±2.02uIU/mL,P<0.05).(5)The partial correlation analysis showed that there were positive correlations between TSH with TG,SBP and DBP,the correlation coefficients were 0.030,0.027,0.029,respectively(all P<0.05),and a negative correlation with HDL-C levels,the correlation coefficient was-0.046(P<0.05);(6)Binary Logistic regression analysis showed that after adjusting for confounding factors,there was a positive correlation between the risk of severe SCH and MS in the total population(OR=1.430,P<0.05)and a positive correlation between severe SCH and elevated blood pressure(OR=1.428,P<0.05),mild and severe SCH with the risks of hyperlipidemiawere both positively correlated(OR=1.181,1.570,respectively,all P<0.05).There were no significant correlations between SCH with risk of central obesity,low HDL-C hyperlipidemia,and elevated blood glucose.Conclusions The prevalence of SCH was 32.1%;elevated TSH levels in SCH patients may increase the risk of MS,elevated blood pressure,and hypertriglyceridaemia.