Analysis Of Syndrome Factors Of PD With Emotional Disorder Based On EFG And Characteristics Of PD Liver Stagnation Syndrome Syndrome

Objective1)To explore the characrteristics of Traditional Chinese Medicine clinic presentations in Parkinson’s disease with mood disorders.2)To analysis the characrteristics of TCM clinic presentations in Parkinson’s disease with liver depression of the heat syndrome.3)To explore the relationship between liver Depression of the heat syndrome and mood disorders in Parkinson’s disease.4)By using encephalofluctuograph(EFG)technology,exame the neurotransmitters of PD patients with emotional disorder and it’s changing rutine in PD patients with liver depression of the heat syndrome.MethodCross sectional study was conducted.The patients with PD were divided into group with mood disorder and group without mood disorder.Whether or not have liver Depression of the heat syndrome syndrome PD patients were divided into group with liver Depression of the heat syndrome and group without liver Depression of the heat syndrome.Into the cases of the general situation,the four diagnostic information,"Ganyuhuare syndrome diagnostic scale","Ganyuhuare syndrome evaluation scale",Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)assessment and clinical professional scale.EFG text was carried out in patients who could be examined.Data collection methods for questions and answers,investigators according to the contents of the observation table for a one to one inquiry and evaluation,is responsible for the results truthfully fill in the observation table.Results1)There was no significant difference in gender,age,age distribution,BMI index,education level,age of onset and course of disease between the groups with mood disorder and group without(P>0.05).2)PD with emotional disorder and emotional disorder group compared to non PD,and low MMSE scores,the difference was not statistically significant(P>0.05);the PDQ-39 score increased significantly,the difference was statistically significant between the two groups(P<0.01);the UPDRS-Ⅲ score is higher,the difference was not statistically significant(P>0.05).3)Compared with the PD group with non-emotional disorder,the frequency of PD and mood disorder was higher,the difference was statistically significant(P<0.05).4)PD with emotional disorder group and PD non emotional disorder group,the mind,heart,liver,heat,qistagnation,yang hyperactivity,yin deficiency score higher,cold score lower,the difference between the two groups was statistically significant(P<0.05).5)Compared with the PD group,the level of mental disorder was more than 2 and grade 3 in the group of PD with emotional disorder,and the concentration of liver,kidney,qi stagnation and yang hyperactivity was more concentrated in grade 3,and the concentration of cold was in grade 0.The difference between the two groups was statistically significant(P<0.05).6)PD with PD group and non emotional disorders mood disorder group,glutamate determination value is higher,the difference was statistically significant between the two groups(P=0.016);5-serotonin,acetylcholine low measured value,the difference was statistically significant between the two groups(P<0.05).7)There was no significant difference in gender,age,age of onset and course of disease between the PD group and the PD group(P>0.05).8)Compared with the PD group,the scores of HAMD,HAMA and PDQ-39 were higher than those of PD group,and the difference between the two groups was statistically significant(P<0.05).9)The scores of liver depression heat syndrome were positively correlated with HAMD,HAMA and PDQ-39 scores(P<0.05),and the correlation coefficients were 0.476,0.546 and 0.485,respectively.10)PD liver stagnation of heat syndrome and non PD Ganyu huare group,mind,heat,dryness,and high frequency in liver stagnation of heat,cold frequency is low,the difference was statistically significant between,the two groups(P<0.05).11)The scores of liver depression and heat syndrome were positively correlated with the scores of heart,liver,kidney,yang hyperactivity and yin deficiency,and the correlation coefficients were:0.540,0.424,0.482,0.427,respectively,0.511.12)PD liver stagnation of heat syndrome and non group compared the difference value of detection of neurotransmitter between the two groups was not statistically significant(P>0.05)13)PD mood disorders group’s liver depression and heat syndrome incidence is higher than non-mood disorder group,the difference was statistically significant(P=0.044).The incidence of depression of liver heat syndrome in PD with emotional disorder group was 7.464 times of the PD non emotional disorder group,and the depression syndrome is a risk of PD(P=0.006).Conclusions1)Mood disorders may be one of the factors leading to the decline in quality of life in patients with PD.2)The mind,heart,liver,heat,qi stagnation,yin deficiency and yang hyperactivity in PD with severity of emotional disorder are more frequent than in PD patients with non-emotional problem.The severity of cold was significantly lower than that of PD patients with non emotional obstacles.3)The increase of GLU and the decrease of 5-HT and ACH may be the neurobiological basis of the emotional disorder in patients with PD.4)The syndrome of liver depression and heat may be the risk factor for PD patients with emotional disorder,and the incidence of liver depression and heat syndrome in PD with emotional disorder group was PD times of non emotional disorder group of 7.464 times.5)The risk factors of anxiety,depression and quality of life in patients with PD may be the liver depression of the heat syndrome.6)The heart,heat,dryness and cold may be the risk factors of PD liver stagnation syndrome.With the increase of the severity of liver stagnation and heat syndrome,the degree of heart,liver and kidney,yang hyperactivity,yin deficiency is more and more serious.