Meta-analysis Of Clinical Efficacy And Safety Of Simple Moxibustion Intervention For Lumbar Disc Herniation

Purpose:Using the Meta-analysis to systematically evaluate the clinical effects and the security of lumbar disc herniation by the treatment of moxibustion.Material and method:Searching the literatures from Pubmed,Embase,CBM,CNKI,VIP,WAN FANG DATA till November 2016.Selecting randomized controlled trial in which using moxibustion to treat lumbar disc herniation in the normal group,while using the acupuncture,the massage,the herb fumigation,the Chinese patent medicine,the Western medicine and other therapies in the control group as the object.2 researchers extract datum from the literatures by reading the title,the abstract and the full text,and do the Meta-analysis for the clinical effects and the security by Revman 5.3.Results:There are 28 literatures in our study,and they are all randomized controlled trials.There are 2429 patients,including 1254 in the normal group in which the patients are treated by moxibustion and 1175 in the control group in which the patients are treated by the acupuncture,the massage,the herb fumigation,the Chinese patent medicine,the Western medicine and other therapies.The course of treatment is unlimited.Randomization is used in the literatures in our study,including 12 literatures in the randomized digital table,one literature in the allocation concealment,one in the single-blind design,five in explanation for the reason of loss to follow-up or quit.The selected literatures have deviation made by selecting,implement and measure.28 selected literatures are evaluated by the improved Jadad scale,including 12 high-quality literatures and 16 low-quality literatures.Datum from all literatures are processed by statistic.Meta-analysis shows the fact given below.The clinical effect of moxibustion is better than that in the control group(RR=1.16,95%CI(1.11,1.21),P<0.00001).Relapse rate of the lumbar disc herniation is better than that in the control group(RR=0.31,95%CI(0.16,0.62),P=0.0009).Compared with the control group,the difference in the aspect of relieving VAS of patients suffered from the lumbar disc herniation has statistical significance(WMD=-1.17,95%CI(-1.56,-0.78),P<0.00001).Compared with the control group,the difference in the aspect of increasing the lumbar function of patientssuffered from the lumbar disc herniation has statistical significance(SMD=3.65,95%CI(2.43,4.88),P<0.00001).Compared with the control group,the difference in the aspect of increasing M-JOA of patients suffered from the lumbar disc herniation has statistical significance(WMD=2.31,95%CI(0.87,3.76),P=0.002).Meanwhile,the moxibustion can reduce the content of IL-6 in serum of patients suffered from the lumbar disc herniation.Conclusion:Moxibustion can effectively relieve the pain of the patients suffered from lumbar disc herniation,improve clinical symptom and reduce the relapse.However,the quality of the selected literatures is ordinary,and the analysis is still circumscribed.So we still need to evaluate by the multicentric and randomized double-blind controlled trial.