The Research Of Micro-porous Osmotic Pump Controlled Release Tablet Of Hippophae Total Flavonoids Solid Dispersion

The total flavones of Hippophae is a general term for extraction of Flavonoids from the dried ripe fruit of Hippophae Elaeagnaceae plants and is the main active ingredient of Sea-buckthorn.The utility model has the pharmacological effects of enhancing human body tolerance,reducing capillary permeability,improving angina pectoris and heart function,and the clinical medicine,which is commonly used for treating cardiovascular and cerebro-vascular diseases,Its curative effect is remarkable,which is recognized by the international medical community.And it need the longer course of treatment and recurrence,ordinary preparation need long-term medication,which based on the total flavones of Hippophae sea-buckthorn that were made of micro-porous osmotic pump controlled release tablets,to overcome the shortcomings of the ordinary preparation,reduce the frequency of drug administration,maintain stable and effective blood concentration,but also can avoid the phenomenon of peak valley ordinary preparation,in order to increase the compliance of patients.Lay the foundation for clinical safe medication.This paper firstly investigated Sea-buckthorn extract traits,TLC,content determination,test items,et al.At the same time it research the quality of control,The method of in vitro analysis was established with the total flavonoids of seabuckthorn as the index component,namely drug dissolution analysis method for determination of mathematics,which can provide the basis for further screening and preparation process in order to improve the quality evaluation.Secondly to improve the total flavones of Hippophae solubility,the solid dispersions we re prepared.Td was determined by Weibull model fitting analysis,and the preparation process was optimized by orthogonal design experiment.The dissolution rate was used as the index to get the best,and the dissolution rate of the drug was evaluated by t he single factor.The solid dispersions of the total flavonoids of Hippophae rhamnoides prepared by the process were studied by SEM,DSC and FT-IR.The stability of the solid dispersions was also investigated.The prepared solid dispersion was prepared as a waterborne intermediate preparation microporous osmotic pump controlled release tablet.The drug release behavior was analyzed by using the similarity factor?₂ method,and the similarity of the dissolution curve was evaluated by single factor test.The types and types of the penetrating agent were investigated in turn.The porogen PEG-400 The amount of plasticizer DBP and the thickness of coating film on the release of drugs,screening to determine the impact of drug release of the main factors for osmot ic pressure penetration agent sodium chloride dosage,porogen PEG-400 dosage and coating film thickness.By using the Box-Behnken response surface method?BBD?to further optimize the formulation,the optimal prescription and technology,and to optimize the prescription of the zero order model,first order model,Ritger-Peppas model,Hixcon-Crowell model and Higuchi model,the results show that the preparation of drug release.The curve fits the zero order model.At the end of this paper,the quality control and stability of the whole flavonoids of seabuckthorn total dispersions were studied.Investigated the preparation of appearance,identification,examination,content and preliminary stability,the results show that high temperature accelerated test and good stability,but in the condition of high humidity,moisture absorption agent is large,so the goods should be stored in shading sealed dry environment.