Clinical Study On Zhuling Decoction Treating Mesangial Proliferative Glomerulonephritis

Objective: To observe the curative effect of Zhuling Decoction in treating primary mesangial proliferative glomerulonephritis(MsPGN),to evaluate the clinical efficacy and safety verification of yin deficiency and dampness heat syndrome in the presence of primary mesangial proliferative glomerulonephritis,and provide clinical data basis for popularize classical prescriptions to treat kidney disease.Methods: Choose from March 2016 to September 2017,Ruikang Hospital affiliated to Guangxi university of Chinese medicine outpatient and ward admitted to the First Affiliated Hospital of Guangxi University of Chinese medicine at the age of 18 to 65 year old patients with idiopathic MsPGN,and urinary protein in 3.0g/d patients.Using the method of random number table,randomly divided into A,B,C three groups,22 cases in each group,which were randomly divided into modern medical treatment group was group A,Group B was used to Tripterygium wilfordii multi glucoside and Jinshui Bao capsul was added to the basic treatment of group A,Group C was the Zhuling Decoction added to the basic treatment of group A.Zhuling Decoction,consisting of: Poria,Polyporus,Alisma,gypsum,gelatin(molten)10g daily,oral Decoction to 200 ML.The three groups were treated with the same basic treatment,medication for 4 weeks as a course of treatment,and evaluate curative effect after 3 courses of treatment.All patients before and after treatment were detected the relevant index: URBC,24 UPRO,ALB,BUN,Scr,TG,TC,LDL-C,HDL-C,1 time every 4 weeks.Blood coagulation function and liver function were detected before and after treatment.At the same time,the clinical symptoms and symptoms improved before and after treatment were observed,and the effect of each group after treatment was compared.Results:(1)Three group patients achieved good curative effect after the treatment,the total efficiency of the A,B,C,three groups were 52.38%,77.27%,90.48%,the effective rate of group C was significantly better than that of group A and B(P<0.05).The curative effect between the three groups was group C > group B > group A(P <0.05).(2)After treatment the TCM syndrome scores of three groups were significantly decreased than before treatment(P<0.01),group C > group B > group A.(3)Three groups after treatment,24 UPRO,TC,LDL-C,and URBC all decreased compared with before treatment,HDL-C,ALB were increased compared with the previous(P<0.05),but the group B and group C were decreased more significantly than the group A(P<0.05),and there was no significant difference between the group B and group C(P>0.05).(4)There was no significant difference in PT,APTT,AST and ALT between of three groups before and after treatment(P>0.05).(5)However,3 cases of upper respiratory tract infection and 1 case of patients with symptoms of dry cough were found in Group A.In Group B,there are 3 patients the symptoms of diarrhea,can restore,not seen aggravating or repeated;2 patients appeared mild abnormal liver function,can improve after the drug was stopped;and 3 patients found hair loss is obvious symptoms,but does not affect the treatment.Patients in group C had no adverse reactions.So that,Zhuling Decoction is safe and effective in clinical application,worthy of clinical application.Conclusion: Clinical curative effect is better that Zhuling Decoction treating mesangial proliferative glomerulonephritis,and urine protein level is less than 3.0 g/d patient.And it can effectively reduce the patients’ TCM symptoms integral.It was illustrated by the curative effect of Zhuling Decoction,Yin deficiency and wet heat treatment symptom is common in the process of the onset of patients with primary MsPGN.