| Objective The enzyme-linked immunosorbent assay(ELISA)method was used to detect the serum adiponectin(APN)levels before and after treatment in the control group and the observation group plus Ginkgo biloba extract injection.Tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were observed in the two groups of follow-up patients with secondary cerebral infarction to investigate the effects of Ginkgo biloba extract on elderly patients.Whether type 2 diabetes can prevent cerebral infarction and its possible mechanism.Methods During the period from June 2016 to June 2017,the clinical data of 50 to90 years old type 2 diabetic patients in the hospital and outpatient departments of the Anhui Provincial Hospital of the People’s Hospital were collected.After exclusion criteria screening,80 elderly patients were included.Diabetes patients were 38 males and 42 females,aged 60-86 years,with an average age of(69.51±7.55)years.All participants were asked about diabetes,hypertension and other related medical history,and blood pressure was measured.Understand the current medication situation,collect general information,including name,gender,age,etc.,and calculate body mass index(BMI)by measuring height and weight.Those who met the criteria for inclusion were randomized into observation group 40 cases and control group 40 cases according to the number table.The control group took conventional treatments such as lipid-lowering,antihypertensive and hypoglycemic treatment.The observation group added intravenous injection of Ginkgo biloba extract injection 20 mL and 0.9%sodium chloride injection solution 250 mL on the basis of routine treatment.1 Times/day,14days for a course of treatment,3 months after the start of the second course of treatment,a total of 2 courses.Fasting venous blood was collected from both groups before treatment and after 2 courses of treatment.The levels of APN,IL-6 and TNF-αwere determined by ELISA.The above indicators of the two groups of patients before and after treatment,adverse drug reactions and follow-up incidence of cerebral infarction after the two groups of patients,the relevant statistical analysis.Results(1)Comparison of APN,TNF-α,IL-6 before and after treatment in observation group and control groupComparison between the two groups:APN levels in the observation group were higher than before treatment(t=8.434,P<0.001),TNF-α(t=11.704,P<0.001)and IL-6(t=9.848,P<0.001),the difference was statistically significant;in the control group,the levels of TNF-αand IL-6 were slightly lower than those before treatment,and the APN was slightly higher,but the difference was not statistically significant.Comparison between the two groups:There was no significant difference in the APN,TNF-αand IL-6 levels between the two groups before treatment.After treatment,the APN level in the observation group was higher than that in the control group(t=4.655,P<0.001).The levels of TNF-α(t=2.128,P<0.05)and IL-6(t=2.285,P<0.05)decreased,and the difference was statistically significant.(2)Comparison of secondary cerebral infarction events in two groupsFollow-up medication within 9 months of the two groups of patients by head CT or MRI examination of new cerebral infarction events,observing the group of cerebral infarction in 1 case,while the control group of 8 cases of cerebral infarction,the observation group was significantly lower than the incidence of cerebral infarction The incidence of the group(χ~2=4.507,P=0.034),the difference was statistically significant.Conclusion(1)Compared with the control group,aged T2DM patients treated with Ginkgo biloba extract significantly decreased the levels of TNF-αand IL-6,and the APN level was significantly increased.(2)The incidence of cerebral infarction was significantly lower in elderly T2DM patients treated with Ginkgo biloba extract than in the control group.Regular treatment of Ginkgo biloba extract injection may be an effective treatment for elderly patients with T2DM to prevent cerebral infarction. |
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