Analysis Of The Multiple Factors Of Prognosis Of Convulsive Status Epilepticus

PART ? Analysis of the clinical features of convulsive status epilepticus Objective:To explore the clinical features of patients with convulsive status epilepticus.Method:(1)The database of 144 patients with CSE diagnosed in the second affiliated hospital of Soochou University from June 2009 to June 2017 was collected and reviewed,including:gender,age,manifestation,past history,etiologic classification,treatment,sodium,chlorine,calcium,potassium,AST,ALT,urea,creatinine,uric acid,blood glucose,lactic dehydrogenase(LDH),creatine kinase(CK),hemoglobin,c-reactive protein(CRP)and pneumonia.(2)Severity and prognosis evaluation:The CSE patient's disease severity was evaluated with STESS.The patient's quality of life and functional recovery prediction was evaluated with END-IT score.The data was analyzed through comparison.Result:(1)According to classification of etiology: the proportion of stroke sequela and remote symptom were the most;(2)According to the STESS,the patients with CSE were divided into two groups: serious and non severe group.The age,creatinine and hemoglobin were significantly different among the two groups(P<0.05).The age of the severe group was larger,the creatinine was higher and the hemoglobin was lower,while the sex,sodium,chlorine,calcium,potassium,magnesium,AST,ALT,urea,uric acid,blood sugar,LDH,CK and CRP were not different between the two groups(P>0.05).(3)Acording to the END-IT score,the patients with CSE were divided into good prognosis group and poor group:The level of uric acid in a good group was significantly higher than that in the bad group(P<0.05),but there was no significant difference in sex,age,sodium,chlorine,calcium,potassium,magnesium,AST,ALT,urea,creatinine,blood glucose,LDH,CK,hemoglobin and CRP between the two groups(P>0.05).Conclusion:(1)According to classification of etiology: the proportion of stroke sequela is the most in adult;(2)According to the STESS grouping:the serious group usually has the characteristics of the older,high creatinine levels and lower hemoglobin;(3)According to the STESS grouping: the blood uric acid level of the good group was significantly higher.PART ? The multivariate analysis of related prognosisfactors of convulsive status epilepticus Objective:The related factors of CSE patients are analyzed by logistic regression analysis to find protective factors and risk factors of disease severity,the quality of life and functional recovery.Method:(1)The database of 144 patients with CSE diagnosed in the second affiliated hospital of Soochou University from June 2009 to June 2017 was reviewed,including: gender,age,manifestation,past,history,etiologic classification,treatment,sodium,chlorine,calcium,potassium,AST,ALT,urea,creatinine,uric acid,blood glucose,lactic dehydrogenase(LDH),creatine kinase(CK),hemoglobin,c-reactive protein(CRP)and pneumonia.The data was analyzed through multiple regression analysis.Result:(1)According to the STESS grouping:age(OR=1.164,P<0.05),past history(OR=26.190,P < 0.05)and pneumonia(OR=25.110,P < 0.05)are therisk factors of CSE patients severity;(2)According to the END-IT grouping:age(OR=1.157,P<0.05),trachea intubation(OR=214.637,P< 0.05),brain lesions(OR=23.843,P<0.05),diazepam withstand(OR=131.073,P<0.05)pneumonia(OR=25.110,P < 0.05)are therisk factors of CSE patients severity.uric acid(OR=0.992,P < 0.05)is the protection factors of the functional recovery and life quality of the CSE patients.Conclusion:(1)Age,merging past history or pneumoniais the risk factors of the CSE patients severity;(2)Higher uric acid is the protection factor of the functional recovery and quality of life in the patients with CSE;(3)Age,brain lesions,trachea intubation and diazepam withstand are the risk factors of the functional recovery and quality of life in the patients with CSE.