The Clinical Research Based On The Principle Of "Zhi Qi" In The Treatment Of Anxiety Disorder With Coronary Heart Disease After Percutaneous Coronary Intervention

Objective: Through observing changes of SAS score、HAMA score、TCM symptom score、WHOQOL-BREF score and hs-CRP、IL-6、TNF-α、5-HT concentration of the patients,evaluating effectiveness and safety of the Yu Xin Decoction for treatment of Qi Deficiency and Blood Stasis Phlegm Syndrome on anxiety disorder with coronary heart disease after percutaneous coronary intervention,which is based on the principle of “Zhi Qi”.The purpose of this study is to provide a new strategy and thinking for treatment of patients with Qi Deficiency and Blood Stasis Phlegm Syndrome on anxiety disorder with coronary heart disease after percutaneous coronary intervention.Methods: A total of 96 patiens with Qi Deficiency and Blood Stasis Phlegm Syndrome on anxiety disorder with coronary heart disease after percutaneous coronary intervention were selected as research object from February 2017 to February 2018 in Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine and The First Affiliated Hospital of Guangxi University of Chinese Medicine,all the patients were divided into 3 groups,the conventional treatment group(32 patiens),Traditional Chinese Medicine group(32patiens),Deanxit group(32 patiens).All patiens were observated for 30 days.All the patients received routine treatment of CHD after percutaneous coronary intervention;And,the Traditional Chinese Medicine group took Yu Xin Decoction;the Deanxit group took deanxit.They were received the evaluaton by SAS,HAMA scale scores,TCM symptom score and WHOQOL-BREF score forms.At the same time,the hs-CRP、IL-6、TNF-α、5-HT content were detected in all of the groups before and after treatment.Through statistical analysis,to compare the statistically significant within and between groups before and after the treatment.Result:(1)After treatment,the Traditional Chinese Medicine group and Deanxit group in the SAS scale and HAMA Scale score were lower than before,and the score difference was statistically significant before and after treatment(P<0.01).After treatment,the conventional treatment group in the SAS scale and HAMA Scale score showed no statistical significance(P>0.05).After treatment,the compare of the Traditional Chinese Medicine group and Deanxit group in the SAS and HAMA score showed no statistical significance(P>0.05).The copare of the HAMA score reduction rate before and after the treatment,the effective rate of Traditional Chinese Medicine group was 77.42%,the effective rate of Deanxit group was 80.65%,between the groups were not statistically significant(P>0.05).The copare of the HAMA score reduction rate before and after the treatment,the effective rate of the Traditional Chinese Medicine group and Deanxit group were higher than the conventional treatment group,there were significant statistical significance(P<0.01).(2)After treatment,the Traditional Chinese Medicine group in the TCM symptom scale score were lower than before,and the score difference was statistically significant before and after treatment(P<0.01).After treatment,the conventional treatment group and Deanxit group in the TCM symptom scale score were lower than before were not obvious,there were not statistically significant(P>0.05).The comparison of curative effect in the aspect of TCM symptom score,the effective rate of Traditional Chinese Medicine group was 87.10%,the conventional treatment group was3.13%,Deanxit group was 6.45%.there were significant statistical significance(P<0.01).(3)After treatment,the Traditional Chinese Medicine group and Deanxit group in the WHOQOL-BREF four areas scale score were higher than before,and the score difference was statistically significant before and after treatment(P<0.01).The Traditional Chinese Medicine group was higher than Deanxit group in the WHOQOL-BREF four areas scale score after treatment in the field of physiological 、 psychological,there were significant statistical significance(P<0.01);in the field of social relations 、environmental,groups differences no statistical significance(P>0.05).the conventional treatment group in the WHOQOL-BREF four areas scale score were higher than before were not obvious,there were not statistically significant(P>0.05).(4)After treatment,the Traditional Chinese Medicine group in the hs-CRP、IL-6、TNF-α content were lower than before,and the score difference was statistically significant before and after treatment(P<0.01).After treatment,the conventional treatment group and Deanxit group in the hs-CRP、IL-6、TNF-α content were lower than before were not obvious,there were not statistically significant(P>0.05).(5)After treatment,the Traditional Chinese Medicine group、Deanxit group in the 5-HT content were lower than before,and the difference was statistically significant before and after treatment(P<0.01).Deanxit group were lower than Traditional Chinese Medicine group,and groups differences was statistical significance(P<0.01).After treatment,the conventional treatment group in the 5-HT content were lower than before were not obvious,there were not statistically significant(P>0.05).Conclusion:1.Yu Xin Decoction can significantly improve the patient’s symptoms of anxiety、TCM symptom and improve the quality of life of the patients with Qi Deficiency and Blood Stasis Phlegm Syndrome on anxiety disorder with coronary heart disease after PCI.2.Yu Xin Decoction can significantly improve the content of hs-CRP、IL-6、TNF-α of the patients with Qi Deficiency and Blood Stasis Phlegm Syndrome on anxiety disorder with coronary heart disease after PCI.3.Yu Xin Decoction can significantly improve the content of 5-HT of the patients with Qi Deficiency and Blood Stasis Phlegm Syndrome on anxiety disorder with coronary heart disease after PCI.But in the short term,Deanxit group than Traditional Chinese Medicine group obviously.