Relationship Between Serum Level Of Vitamin A,E And Pre-eclampsia In Pregnancy

Preeclampsia(PE)is a special disease of pregnancy which seriously effects the health of mother and baby.It usually refers to the diseases characterized by hypertension and proteinuria after 20 weeks of gestation,often involving the heart and brain,liver,kidney and other important organs,is the maternal and perinatal morbidity and mortality of one the main reasons.for its incidence in foreign countriesOxidative stress(OS)is a hot research topic in the pathogenesis of preeclampsia.As a result of placental ischemia-anoxia-reperfusion injury caused by a series of oxidative factors,vascular endothelial damage,eventually leading to the progression of the disease and poor prognosis of preeclampsia.In recent years,the researches of supplemental antioxidant vitamins on the prevention of preeclampsia in vivo are increasing,vitamin A,E are strong antioxidants,Its level in pregnant women serum and its correlation with preeclampsia rarely seen at home and abroad,This study retrospectively analyzed the serum levels of vitamins A and E and their correlation with preeclampsia in pregnant women aged 12-20 weeks.It also discussed whether vitamins A and E could be used as a biological test before clinical symptoms of preeclampsia.ObjectiveBy collecting pregnant women before 20 weeks of pregnancy serum vitamin A,E levels,explore their correlation with preeclampsia.To compare the levels of vitamin A and E in the serum of pregnant women and healthy pregnant women with preeclampsia and predict the correlation between the levels of vitamins A and E and preeclampsia before 20 weeks’ gestation,and to provide new serum biological indicators for the prediction of preeclampsia in the early pregnancy.Materials and methodsA retrospective analysis of 1451 pregnant women who were routinely diagnosed at the Third Affiliated Hospital of Zhengzhou University from January 2015 to May 2017 and serum vitamin A and E levels were detected at 12-20 weeks was carried out.Among them,the cases of preeclampsia(PE group)were 211 cases,healthy pregnant women into the group of 1240 cases.Inclusion criteria: age 18 to 42 years,mean(29.8±5.6)years old,single live births.Exclusion criteria: history of preeclampsia,essential hypertension,had pregnancy-induced hypertension and other endocrine disorders.Criteria for the diagnosis of preeclampsia reference People’s Health Publishing House "Obstetrics and Gynecology" eighth edition textbook diagnostic criteria.Case data collected for serum vitamin A and E at 12-20 weeks of gestation : name,age,serum vitamin A,E levels,contact information;After childbirth,complete case information is collected again according to the content of the previous collection: name,age,height,prenatal weight,weight gain during pregnancy,gravidity,parity,pregnancy outcome,contact information.Serum vitamin A and E concentrations were determined by high performance liquid chromatography.Statistical methodsAll the complete data were collected and entered into the Excel table in turn,and using SPSS 21.0 software to import into form,and then carried on the statistical analysis.All measurement data were expressed as the mean ± standard deviation(X±SD),The statistical analysis of measurement data were using t-test;all counting data were expressed as percentage(%),the statistical analysis of counting data were using chi-square test,and the above two methods were used to perform single variables for each variable;then univariate analysis of meaning variables were performed using logistic regression analysis.Using α=0.05 as a reference standard,P<0.05 was considered statistically significant.Result1 Results of univariate analysis1.1 The level of serum vitamin E in pregnant women with PE is higher than those in healthy controls,with statistical significance(P<0.05);the level of serum vitamin A between the two groups is not statistical significance(P>0.05);1.2 The prenatal BMI,advanced age,increased BMI in PE group were significantly different from those in healthy control group,with statistical significance(P < 0.05);1.3 There was no significant difference in pregnancy grade and parity between PE group and healthy control group(P>0.05);2 Multivariate logistic regression analysisEntering all the variables with statistically significant into logistic regression analysis,the results shows that the level of serum vitamin E,prenatal BMI and age were the independent factors of the preeclampsia.2.1 The high level of serum vitamin E in the pregnant women is an independent risk factors for PE,the OR value(95% confidence interval)is 1.168(1.043,1.308);2.2 The maternal advanced age is an independent risk factor for preeclampsia,the OR value(95% confidence interval)is 3.897(2.083,7.293),P=0.000;2.3 The maternal prenatal BMI is an independent risk factor for preeclampsia,the OR(95% confidence interval)is 1.287(1.221,1.385),P=0.000;2.4 The increased BMI during pregnancy is not an independent risk factor for preeclampsia,P=0.052.ConclusionThere is a close relationship between vitamin E and preeclampsia,and before the onset of clinical symptoms of preeclampisia,the level of vitamin E occur abnormal,and vitamin E may become a predictor biological indicators of preeclampsia.