Analysis Of The Characteristics Of Thyroid Nodules And Risk Factors Of Thyroid Nodules In Glycometabolism Disorders Of Population In Hefei Communities

Objective To investigate the characteristics of thyroid nodules and risk factors of thyroid nodules in glycometabolism disorders of population in Hefei communities.Methods According to random data table method,a total of 388 subjects were randomly selected as the objects of this research from 1 425 permanent residents aged 18 years or older from Changqing community of Baohe district in Hefei city,and all underwent a 75 g oral glucose tolerance test(OGTT).They were divided into normal blood glucose group(NGM group)and abnormal glucose metabolism group(AGM group)by blood glucose levels.Clinical data,laboratory examination results,and thyroid B-ultrasonic examination were recorded.The multiple logistic regression analyses were performed to assess the related risk factors for thyroid nodule.Results(1)Compared with individuals in NGM group,body mass index,waistline,systolic blood pressure,fasting plasma glucose,two-hour plasma glucose during OGTT,glycosylated hemoglobin A1 c,triglyceride,total cholesterol,low-density lipoprotein-cholesterol,serum uric acid levels,positive rate of thyroid peroxidase antibody as well positive rate of thyroglobulin antibody were significantly higher in individuals than in NGM group(P<0.05).By contrast,high-density lipoprotein-cholesterol were significantly lower in individuals than in NGM group(P<0.05).(2)The detection rates of thyroid nodule and multiple nodules in AGM group were 27.5%,7.3%,respectively,which were all higher in AGM group than in NGM group(P<0.05).However,there were not significant difference in the detection rates of solitary thyroid nodule,left leaf nodule,right leaf nodule,two leaft nodule,nodule longer than 1cm,thyroid nodule with calcification and dense echo between AGM group and NGM group.(3)Compared with individuals in the group without thyroid nodule,the female proportion、BMI、WC、SBP、FPG、2 h PG、Hb A1c、TG、FIns、HOMA-IR、SUA、MUI、positive rate of TPOAb and Tg Ab were significantly higher in individuals than in the non-thyroid nodule group(P < 0.05).There was no significant difference between the two groups in the age、 DBP、TC、HDL-c、LDL-c and TSH(P > 0.05).(4)Multivariate Logistic regression analysis showed that serum uric acid level,median urinary iodine,thyroid antibody level and abnormal glucose metabolism were independently associated with a statistically significant increase in the risk of thyroid nodule(P<0.05).Conclusion Abnormal glucose metabolism increases the risk of thyroid nodule in Hefei communities.It is necessary to carry out thyroid nodule screening and take appropriate intervention measures in individuals with abnormal glucose metabolism.