The Relevant Analysis Of Plasma Homocysteine And Atherosclerotic Disease

Objective:To investigate the correlation between homocysteine and atherosclerotic disease,and the independent risk factors for hyperhomocysteinemia in patients with atherosclerotic disease.METHODS:From July 2017 to September 2017,301 patients with atherosclerotic disease diagnosed in Department of Cardiology,Neurology,and Vascular Surgery at the First Hospital of Jilin University were selected as the experimental group and divided into acute coronary syndrome group126 Cases,82 patients with acute cerebral infarction,93 patients with severe arteriosclerosis obliteration,69 patients with definite acute coronary syndrome,acute cerebral infarction and severe arteriosclerosis obliteration as Normal control group.At the same time,the above 301 patients with atherosclerotic disease were divided into homocysteine group according to homocysteine levels in 118 cases(homocysteine ≥ 15mmol/L)and homocysteine normal Group(homocysteine <15 mmol/L)183 cases.Results:1.Comparison of homocysteine levels in people with atherosclerotic disease in different systems:(1)Homocysteine levels in patients with atherosclerotic disease were higher than those in controls.The difference was statistically significant.Significance(p<0.001).(2)Homocysteine levels in patients with different system atherosclerotic disease,the difference was not statistically significant(p=0.361).2.Homocysteine levels were used to identify coronary atherosclerosis analysis of the effects of acute coronary syndrome,acute cerebral infarction and severe arteriosclerosis obliterans:(1)Differential diagnosis of acute coronary syndrome with homocysteine,area under ROC curve was 0.820,95% CI was 0.762-0.877,p <0.001,when Hcy ≥ 12.03 mmol/L was diagnosed as acute coronary syndrome,the diagnostic sensitivity at this time was 60.31%,the specificity was 98.55%,and the norden index was 0.589.(2)homocysteine for differential diagnosis Analysis of the effect of acute cerebral infarction,ROC analysis showed that the area under the curve was 0.701,95% CI was 0.629 to 0.773,p <0.001,when the diagnosis of acute cerebral infarction with Hcy ≥ 11.25,the diagnostic sensitivity at this time was 74.39%,specificity It is 62.54% and the Yodner index is 0.369.(3)Analysis of the effect of homocysteine in the differential diagnosis of severe arteriosclerosis obliterans.ROC analysis showed that the area under the curve was 0.818,95% CI was 0.753-0.883,p < 0.001.Severe atherosclerosis was diagnosed when Hcy ≥ 10.85.In occlusive disease,the diagnostic sensitivity at this time was 77.11%,the specificity was 85.51%,and the Yoden index was 0.586.3.Analysis of Factors Affecting Hyperhomocysteinemia in Patients with Atherosclerotic Diseases: Analysis of General and Related Biochemical Indices of Patients in the Two Groups,Analysis of Results Showing Hyperhomocysteinemia in Patients with a History of Smoking The rates were higher than their relative conditions,and the differences were statistically significant.The age,creatinine,and urea nitrogen of the homocysteine group were higher than those of the normal homocysteine group.The differences were statistically significant;Hemoglobin in homocysteine group was lower than that in homocysteine group,and the difference was statistically significant.4.Multivariate logistic regression analysis of factors influencing hyperhomocysteinemia showed smoking history and creatinine In order to influence the independent risk factors for hyperhomocysteinemia,hemoglobin is an independent protective factor affecting hyperhomocysteinemia.Conclusions:1.Homocysteine levels were elevated in patients with atherosclerotic disease compared with healthy subjects.There was no significant difference in homocysteine levels in patients with different system atherosclerotic diseases.2.Determination of homocysteine levels has diagnostic value for atherosclerotic disease.3.Smoking and creatinine were independent risk factors of Homocysteineemia.Hemoglobin was an independent protective factor affecting hyperhomocysteinemia.Age,urea nitrogen,and homocysteine were also correlated.