Effect Of High-flux Hemodialysis Affect On Cardiovascular Calcification In Maintenance Hemodialysis Patients And Its Clinical Significance

Objective: To investigate the effects of high flux dialysis on maintenance of hemodialysis（MHD）patients’ serum creatinine,serum phosphorus,serum calcium,parathyroid hormone（PTH）,soluble α-Klotho protein（s KL）,fibroblast growth factor（FGF-23）levels,and cardiovascular calcification.Methods: From June 2016 to June 2017,Forty-nine patients with uremia who underwent regular hemodialysis at the hemodialysis center of the First Affiliated Hospital of Nanhua University were enrolled,and randomly divided into 28 patients with high-flux hemodialysis group（HFD）.,while 21 patients with low flux dialysis group（LFD）.The basic data of the two groups,including gender,age,dialysis age,primary disease,and taking phosphorus-lowering drugs,were not statistically different（p>0.05）.Before the study,there was no significant difference in the indicators of peripheral blood such as Scr,Ca²⁺,Pi3-,PTH,FGF-23,and s KL（p>0.05）.The time of each hemodialysis and the components of the dialysate were the same in both groups,and the observation time was 6 months.At the beginning of the study and at the end of 6 months,blood samples of the patients were taken and tested for serum calcium(Ca²⁺),serum phosphorus（Pi3-）,serum creatinine（Scr）,parathyroid hormone（PTH）,and fibroblast growth factor-23（FGF-23）and soluble α-Klotho protein（s KL）concentrations,using cardiac echocardiography to assess cardiovascular calcification before and at the end of treatment.Result: After treatment in patients in the HFD group,blood Scr decreased,blood Ca²⁺ decreased,and s KL levels decreased,but the difference was not statistically significant（p>0.05）;blood Pi3-,FGF-23,and PTH levels were significantly decreased,the difference was statistically significant（p <0.05）.The blood Scr levels in patients with LFD group were lower than those before treatment,and there was no significant change in serum Ca²⁺（p>0.05）.The levels of blood Pi3-,FGF-23,and PTH were decreased,but the difference was not statistically significant（p >0.05）;the s KL level was significantly lower than before treatment.The difference was statistically significant（p<0.05）.There was no significant change in cardiovascular calcification in patients before and at 6 months of treatment（p>0.05）.There was no statistically significant change in cardiovascular calcification between the high-pass and low-pass groups（p>0.05）,but the incidence of simple aortic valve calcification was higher in heart valve calcification.Conclusion: High-flux hemodialysis can improve phosphorus metabolism disorder,effectively reduce the level of parathyroid hormone in maintenance hemodialysis patients,better remove serum FGF-23,and better protect the expression of Klotho protein in vivo,from multiple perspectives Delaying the progression of cardiovascular calcification in maintenance hemodialysis patients is more worthy of clinical promotion.