A Study Of The Clinical Characteristics,Treatment And Prognosis Of Guillain-Barre Syndrome

Objective:To investigate the clinical features of Guillain Barre syndrome in Xinjiang,different treatment methods for the clinical evaluation of Guil lain Barre syndrome patients and the analysis of factors affecting the prog nosis of Guillain Barre syndrome,for the prognosis of patients with Guillain Barre syndrome with predictive factors.Methods:Continuous retrospec tive collection in December 2012-August 2017 in the First Affiliated Hos pital of Xinjiang Medical University Department of Neurology of the 110 cases were diagnosed as Guillain Barre syndrome among Han and Uygur patients with clinical data,laboratory data,electrophysiological data,methods of treatment and factors associated with the disease,according to the Hughes score out of the hospital is divided into good prognosis group(ΔHughes<0)and poor prognosis group(ΔHughe≥0),and a comparison between the two groups of clinical,electrophysiological,biochemical indicators of the prognosis;through Logistic regression analysis to explore the rel ated factors that predict a bad outcome.Results:In 110 patients,including 68 cases of male,female 42 cases;63 cases of Han Uygur nationality;47 cases;the average age(46.88+16.62)years old,were classified accordi ng to the clinical symptoms and EMG data,including AIDP 59 cases,AM AN 51 cases,according to the comparison of single factor electrophysiological type grouping in between the two groups of gender,age,season,area of residence,initial symptoms,cranial nerve damage,autonomic nerve damage,respiratory muscle involvement,CSF pressure,protein cell separati on,no significant difference(P>0.05);group,before the flooding may be factors,pre admission course and electrophysiological classification about(P<0.05);in GBS therapy,hormone therapy,immunoglobulin and immunog lobulin + hormone therapy group is better than the general curative effect,the immune globulin group better efficacy In hormone therapy group,the re was no difference in hormone therapy,immunoglobulin therapy and immunoglobulin plus hormone treatment in type AIDP GBS.The effect of immunoglobulin in AMAN GBS was better than hormone therapy.In multivariate analysis,age more than 60 years old(P<0.001,OR=8.867,OR,95%CI:3.019-26.043)with respiratory muscle(P=0.003,OR=22.657,OR,95%CI:2.842-180.63)(P=0.012,OR=2.976,cranial nerve involvement,OR,95%CI:1.269-6.978)is associated with poor clinical prognosis.Conclusion:There are more males than females in Xinjiang area.High onset in summer,The peak age of onset is 41-50.The incidence of diarrhea in North ern Xinjiang is more than that of women.Most of the precursors are diarrhea,mostly with limb weakness.The duration of hospitalization is less than 2 weeks.The Han population is susceptible to AMAN type GBS,and the Uygur population is susceptible to AIDP type GBS.The patients wit h diarrhea as a precursor were easily developed into type AMAN GBS,and the course of AMAN before admission was more than that in group AIDP within two weeks.There was no difference in the efficacy of three tr eatments in type AIDP GBS,and immunoglobulin in type AMAN GBS was superior to hormone therapy.60 years of age or older patients with respiratory muscle involvement in GBS patients with cranial nerve involvement in GBS patients with poor prognosis.