Correlation Analysis Between Cold Dampness Syndrome Type,Deficiency Of The Liver And Kidney Type Of Rheumatoid Arthritis And Laboratory Indexes

Objective:According to the statistical analysis of clinical symptoms and laboratory indexes of rheumatoid arthritis,the study investigates the correlation between cold dampness syndrome,deficiency of liver and kidney and the clinical symptoms and the laboratory indexes,hoping to provide objectively theoretical references for TCM classification of rheumatoid arthritis.Methods:According to the inclusion criteria,90 patients newly diagnosed with rheumatoid arthritis were selected,who were divided into 2groups:47 cases as cold dampness syndrome group and 43 cases as deficiency of liver and kidney.The age,sex,symptoms and laboratory indicators,such as PLT,ESR,CRP,RF,CCP,AKA of two groups of patients was recorded as they were admitted to the hospital.After 4 weeks of treatment with the combination of TCM and western medicine(Methotrexate,Leflunomide),extra hospital preparation,acupuncture,etc.,the researcher recorded the data of clinical symptoms and laboratory indicators of the examination items.It analyses the relationship between two groups of TCM syndrome types and general data,clinical symptoms and laboratory indexes,via the statistics software of SPSS20.0.It also Analyses the relationship of the improvement of clinical symptoms and laboratory indicators after treatment,exploring the correlation between cold dampness syndrome,deficiency of liver and kidney syndrome and the clinical symptoms and laboratory indexes.Results:1.Comparison of the general data of two groups:The average age of cold dampness syndrome is 48.5±5.16,the average age of deficiency of liver and kidney is 58.2±5.52,the average age of deficiency of liver and kidney is older than that of cold dampness syndrome,thus the difference had statistical significance(P<0.05).The difference in sex had no statistical significance.(P>0.05).2.Correlation between the two TCM syndrome types and the clinical symptoms:joint pain index,swelling index,morning stiffness time of joint and DAS28 score of cold dampness syndrome are all greater than deficiency of liver and kidney syndrome,thus the difference had statistical significance(P<0.05);the HAQ score between two TCM Syndrome types was compared,and the difference had no statistical significance(P>0.05).3.Correlation between the two TCM Syndrome types and the laboratory indexes:The average RF and the positive rate of RF and AKA of deficiency of liver and kidney were greater than cold dampness syndrome(P<0.05);there was no big difference between two TCM Syndrome types in PLT,ESR,CRP,CCP(P>0.05).4.The correlation between the two TCM Syndrome types and the improvement in clinical symptoms:the D-value before and after treatment in joint pain index,swelling index,morning stiffness time of joint,DAS28 score and HAQ score as to the two groups of clinical indicators was not obvious,thus it had no statistical significance(P>0.05).5.The correlation between the two TCM Syndrome types and the improvement in laboratory indicators:After treatment,the laboratory indexes of two groups were significantly decreased.Before and after treatment,both the RF mean difference and AKA positive rate difference of deficiency of liver and kidney were greater than those of cold dampness syndrome(P<0.05);The difference of PLT,ESR,CRP,CCP between two groups Before and after treatment had no statistical significance(P>0.05).Conclusion:1.The average age of deficiency of liver and kidney is older than cold dampness syndrome;Two groups had no big difference in sex.2.Pain index,swelling index,morning stiffness time of joint and DAS28can be used as a reference type of cold dampness syndrome and deficiency of liver and kidney;HAQ score can~’t be used as the basis for the classification of the two groups syndromes.3.The laboratory indicators of RF and AKA can be used as a reference to distinguish cold dampness syndrome and deficiency of liver and kidney;PLT,ESR,CRP and CCP are difficult to distinguish syndrome between the two groups,so these indicators can~’t be used as the basis to distinguish the syndrome types between the two groups.