Value Of ¹⁸F-FDG PET/CT Combined With The Same Scanner Hrct In The Diagnosis Of Pulmonary Ground-glass Nodule

BackgroundTo investigate the value of 18F-FDG PET/CT combined with the same scanner HRCT in the diagnosis of pulmonary ground-glass nodule(GGN).Material and MethodsA total of 72 patients with pulmonary GGN were retrospectively analyzed,which were confirmed by surgical pathology or clinical follow-up.The clinical data,imaging features,maximum standardized uptake value(SUVmax)were analyzed statistically.The diameter of the nodule and SUVmax were plotted as receiver operating characteristic curve(ROC)and the optimal truncation value was obtained.ResultsOf the 72 patients with GGN,40 cases were malignant and 32 cases were benign.Univariate analysis showed that there were significant differences in diameter(t=4.932,P<0.001),density type(χ2=29.425,P<0.001),lobular sign(χ2=9.626,P=0.002),spiculation sign(χ2=7.605,P=0.006),pleural indentation(χ2=4.585,P=0.032),vascular convergence(χ2=7.605,P=0.006)and SUVmax(t=3.884,P<0.001),but no difference in gender(χ2=0.026,P=0.873),age(t=1.417,P=0.161),vacuole sign(χ2=3.214,P=0.073)and air bronchus sign(χ2=1.664,P=0.197)between the two groups in HRCT.Multivariate analysis showed that mixed density was a remarkable predictor of malignancy(χ2= 10.261,OR=23.515,P<0.05).ROC showed that taking the diameter≥11mm and SUVmax≥0.9 as the malignant standard reference indexes have a good identification accuracy.The sensitivity of HRCT,PET/CT and PET/CT combined with the same scanner HRCT in the diagnosis of GGN were 75.0%,82.5%,90.0%;the specificity and accuracy of which were 81.3%,78.1%,68.8%and 77.8%,80.6%,80.6%respectively.Conclusion18F-FDG PET/CT combined with the same scanner HRCT has a certain clinical value in differential diagnosis of GGN by analyzing the metabolic condition and imaging characteristics and can improve the sensitivity of diagnosis.