Influence Of Obesity On The Pathological Features And Biochemical Recurrence In Prostate Cancer Patients Undergoing Radical Prostatectomy After Neoadjuvant Hormonal Therapy

objective: This study aimed to investigate the relationship between obesity and pathological features and biochemical recurrence in prostate cancer patients undergoing radical prostatectomy(RP)after neoadjuvant hormonal therapy(NHT).Methods: A total of 422 consecutive patients with clinically high-risk localized prostate cancer who received NHT before RP were retrospectively analyzed.Clinicopathological data including age,height,weight,smoking status,PSA levels at diagnosis,biopsy Gleason scores,clinical stage,pathological stage,lymph node involvement,extraprostatic extension,seminal vesicle involvement,positive margins and time of biochemical recurrence were collected.Patients were divided into two groups according to BMI.Comparisons of the two groups were performed using Chi-squared tests.Unconditional multiple logistic regression was used to estimate odds ratios(ORs)and 95% confidence intervals(CIs)regarding correlation.A receiver operating characteristic(ROC)curve was used to assess the efficacy of obesity.Biochemical recurrence free survival curves were obtained using the Kaplan–Meier method,and were compared using the log-rank test.Results: Positive margin was more prevalent in the obesity group(P=0.03).Obesity was associated with an increased risk of positive margins(OR=2.281;95%CI:1.292–4.028)after adjusting for potential confounders.The area under the ROC curve of the model with BMI was larger than that without BMI.There was no significant difference between the obesity and normal weight groups regarding biochemical recurrence free survival(P>0.05).Conclusions: Obesity was strongly associated with positive margins in prostate cancer patients undergoing RP after NHT.