Correlation Between Abdominal Fat Distribution And Colorectal Adenomatous Polyps Evaluated By CT

Objective:To investigate the correlation between visceral fat area,subcutaneous fat area,total fat area,visceral fat area/total fat area and colorectal adenomatous polyps based by CT.Methods:From January 2014 to October 2017,438 patients with abdominal CT and colonoscopy at the Fourth Affiliated Hospital of China Medical University were collected,including 225 pathologically confirmed CAP patients and 213 patients with abnormal colorectal mucosa.First,their general clinical datas and VFA,SFA,TFA,VFA/TFA of umbilical plane were recorded.The correlation between abdominal fat distribution and CAP of subjects included were analyzed.Then,grouped by sex,the differences of abdominal fat distribution and the impact on CAP were compared between different genders,and the ROC curve of CAP independent risk factors was maked.Finally,we performed a statistical analysis of the relationship between VFA,SFA,TFA,VFA/TFA and CAP-related features(number,pathological outcome,and extent of progression)between different genders.Results:1.VFA,VFA/TFA and the incidence of CAP was statistically significant.Multivariate analysis showed the odds ratios of the highest quartile were 2.352 and 2.381respectively,with P values of 0.003 and 0.002,respectively.2.VFA,SFA and VFA/TFA between men and women were statistically significant,P values were all less than 0.001.Multivariate analysis showed that the incidence of VFA and CAP in male group was statistically significant,the odds ratio of the highest quartile was 2.858,P value was 0.005.The risk of VFA,VFA/TFA and CAP in the female group was statistically significant,the odds ratios of the highest quartile were 4.088 and 6.179,respectively,with P values of 0.009 and 0.001,respectively.3.The area under the ROC curve of male VFA value was 0.583,the best diagnostic cutoff point was 189.89cm~2.The area under the ROC curve of female VFA value was 0.594,the best diagnostic cutoff point was 122.10cm~2 respectively.The area under the ROC curve of female VFA/TFA was 0.641,the best diagnostic cutoff was 0.395.4.There was a statistically significant difference in VFA/TFA and CAP progression in females,P was 0.027.Conclusion:1.Excess visceral adipose tissue is an important risk factor for the pathogenesis of CAP.2.In the male population,visceral fat content is closely related to the risk of CAP,the best diagnostic cutoff point is 189.89cm~2,while in the female population,the visceral fat content and visceral fat to total fat ratio are independent risk factors for CAP,their diagnostic cutoff points were 122.10cm~2and 0.395 respectively.3.The proportion of visceral fat in total fat in females is positively correlated with the progress of CAP.