Relationship Between Serum Galectin-3 Levels And The Severity Of Coronary Atherosclerosis

Objective: Study on the correlation between the level of serum galectin-3 and the severity of coronary atherosclerosisMethods: A total of 120 patients with coronary heart disease and suspected coronary heart disease were collected between December 2016 and December 2017 in the People's Hospital of Hebei Province.The patient underwent invasive coronary angiography.Two angiographers were provided at the intervention center of the People's Hospital of Hebei Province to evaluate the Gensini score of coronary artery disease.According to clinical classification,plaque stability,coronary angiography as a result,all the eligible patients with a total of 120 patients,divided into acute myocardial infarction(Acute Myocardial Infarction,AMI)and unstable angina pectoris(Unstable Angina Pectoris,UAP)group,stable angina pectoris(Stable Angina Pectoris,SAP)group and control group in four groups.In patients with coronary angiography positive performs the following criteria: the anterior descending left main,and maneuver,at least a blood vessel in the right coronary artery or its main branches stenosis degree 50% or greater,the control group patients do not meet above criteria.Myocardial enzyme,electrocardiogram and other examinations were performed immediately after admission.The history of diabetes,age,sex and smoking history were recorded.Smoking criteria: smoking for more than 1 year,smoking more than1 a day.All patients were measured on the second day of fasting blood glucose level on the second day,and the supine position was measured 4 times in quiet state.The measurement was measured for 3 minutes at two intervals,and the average was calculated.Using ELISA to determine serum concentration of serum galactose-3(Galectin-3,Gal-3),use special computer software for coronary scoring.Results: Compared with the four groups,the serum level of gal-3 was significantly higher than that of the control group,P <0.05,and the difference was statistically significant.With acute myocardial infarction or unstable angina group,stable angina group serum galactose lectin-3 group were significantly lower than that of acute myocardial infarction or unstable angina pectoris group,difference have statistical significance;Compared with the unstable angina group,acute myocardial infarction group was significantly higher than that of the unstable angina group,and the difference was statistically significant.Gensini scores in the four groups were statistically significant.The Gensini score in the acute myocardial infarction group or the unstable angina group was higher than the stability angina group,and the difference was statistically significant.The Gensini score of the acute myocardial infarction group was higher than that of the unstable angina group,and the difference was statistically significant.The level of gal-3 serum level was positively correlated with patients with AMI and UAP group.Conclusion:1.Serum galactose-3 is positively correlated with the degree of coronary artery stenosis.2.Serum galactose-3 is associated with the instability of coronary atherosclerotic plaque and has predictive value for the instability of coronary atherosclerotic plaque.