The Influence Of Dexmedetomidine(Dex) Of Different Infusion Rate To The Patients Undergoing Subarachnoid Block

Objective To observe the basic vital signs,sedation,BIS and postoperative analgesia change of dexmedetomidine(Dex)on different infusion rate in the patients undergoing subarachnoid block.Methods Eighty patients of lower limb operation,ASA Ⅰ or Ⅱ,were randomly devided into four groups with 20 people each:group D1,Dex was infused in 10 min in a dose of 0.6 ug/kg(Dex,4ug/ml,0.15ml/kg),group D2,Dex was infused in 15 min with the same does(Dex,4ug/ml,0.15ml/kg),group N1,saline of 0.15ml/kg was infused in 10 min,group N2,saline of 0.15ml/kg was infused in 15 min.BIS,SBP,DBP,HR,Sp02 and OAA/S were recorded at before subarachnoid block,15min after subarachnoid block and 1,3,5,10,15,20,30,45,60,75,90,105,120 min after Dex administration.Record visual analogue scale(VAS)score after 6 and 9 hours after subarachnoid block.Results Compared with the group N1,Dl’s HR decreased at T4～T8,OAA/S fell at T5～T10,the BIS fell significantly at T3～T12,VAS scores at Th1 and Th2 was significantly lower,patients who use analgesics was noticeably reduced(P<0.05);Compared with the group N2,D2’s HR decreased at T4～T8,OAA/S fell at T6～T10,the BIS fell significantly at T4～T12,VAS scores at Th1 and Th2 was significantly lower,patients who use analgesics was noticeably reduced(P<0.05);Compared with the group D1,D2’s OAA/S increase significantly at T5,the BIS fell significantly at T11(P<0.05).Conclusions Dex infusion in the does of 0.6ug/kg has sedative effect and analgesia after operation in the patients undergoing subarachnoid block,the smaller infusion rate,the littler change on blood pressure and HR,the more safer.