Clinical Observation On Treatment Of Threatened Abortion With Subclinical Hypothyroidism By Bushen Antai Decoction And Youjiale

Objective:This subject focuses on observing the clinical efficacy of traditional Chinese medicine Bushen tocolysis combined with levothyroxine sodium tablets in the treatment of early threatened abortion combined with subclinical hypothyroidism,to monitor the improvement of pregnancy-related hormones and thyroid hormones,follow-up of pregnancy outcome and explore its mechanism of action to reduce spontaneous abortion Rate and impact on pregnant women and fetuses.Methods:This Study collected sixty cases of nephrothiasis with threatened abortion combined with subclinical hypothyroidism,which were randomly divided into two groups:treatment group and control group.The basic treatment of the two groups was intramuscular injection of progesterone 20 mg qd.The control group of thirty patients（to be treated with levothyroxine sodium tablets）,the treatment group of thirty patients（to be Chinese medicine Bushen tocolysis+levothyroxine sodium tablets treatment）.The course of treatment is four weeks.The changes of observational indexes and pregnancy outcomes before and after treatment in both groups were observed.Results:1.The comparison of comprehensive efficacy:The total effective rate of the treatment group was 93.3%and the control group was 70%.The difference between the two groups was statistically significant（P<0.05）;2.The comparison of Pregnancy related hormones（P,E₂）:the difference of the two groups was not statistically significant（P>0.05）before treatment;the difference of the identical group before and after treatment was statistically significant（P<0.01）;The difference of treatment group and the control group was statistically significant（P<0.01）.The results showed that both groups were effective after treatment.In addition,the treatment group was significantly better than the control group in improving progesterone and estradiol levels;3.The comparison of Thyroid related hormones（FT3,FT4,TSH）:the difference of the two groups in FT3,FT4 and TSH levels was not statistically significant（P>0.05）before treatment,the difference of the FT3 values between the two groups of patients with after treatment and before treatment was not statistically significant similarly（P>0.05）,proved that this therapy has no significant effect on the change of FT3 level;After treatment in both groups,the FT4 level was higher than before treatment,but it was still within the normal range.The difference was statistically significant（P<0.01）while it was not statistically significant（P>0.05）between the two groups after treatment,showed that the treatment could increase the value of FT4 and the efficacy is comparable to that of the control group;After treatment in both groups,the TSH level was lower than before treatment and the difference was statistically significant（P<0.01）;In addition,the difference was statistically significant（P<0.01）between the two groups after treatment,indicating that the treatment group was significantly better than the control group in reducing the TSH level;4.The comparison of TCM syndrome scores:Before treatment,there was no significant difference between the two groups（P>0.05）;There was significant difference between the two groups before and after treatment（P<0.01）.The curative effect of the treatment group on improving TCM syndromes was better than that of the control group and the difference was statistically significant（P<0.01）.The result showed that the treatment group could significantly improve TCM syndromes;5.The comparison of pregnancy outcomes:Pregnant women:There was no significant difference between the treatment group and control group in the incidence of pregnancy-induced hypertension and preterm birth（P>0.05）;The incidence of gestational impaired glucose tolerance of the control group was significantly higher than that of the treatment group,the difference was statistically significant（P<0.05）;Neonatal:The incidence of neonatal asphyxia and low body weight in the treatment group was significantly lower than that in the control group,the difference was statistically significant（P<0.05）;It showed that the treatment group could significantly reduce the incidence of pregnancy complications;Conclusion:Chinese medicine Bushen tocolysis combined with levothyroxine sodium tablets showed visible clinical efficacy in treatment of early threatened abortion combined with subclinical hypothyroidism,which could significantly improve thyroid function and pregnancy-related hormones levels,but also reduce the incidence of pregnancy complications and improve the quality of life of newborns correspondingly.Its mechanism needs to be further explored.