Clinical Study Of The Low Frequency Transcranial Magnetic Stimulation In The Treatment Of Parkinson’s Disease

Purpose: To explore the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation(r TMS)in Parkinson’s disease(PD)patients.Methods: Twenty-eight PD patients were randomly divided into 2 groups,Group Treatment and Group Sham.We applied low frequency r TMS(110% of motor threshold,1 Hz)over the dorsolateral prefrontal cortex(DLPFC)in Group Treatment for ten days.Group Sham were given a sham stimulation.We followed up the patients when the treatment finished,one month later,three months later,six months later and twelve months later.Results: The changes in the Unified Parkinson’s Disease Rating Scale part III(UPDRS-III)scores were significantly greater when comparing the baseline to the scores of finish the stimulation,one month after the stimulation,there month after the stimulation and six month after the stimulation.The Hamilton Rating Scale for Depression(HDRS)has a similar result until three month.Conclusions: The low-frequency r TMS(right DLPFC)can improve the motor function and depressive symptoms in PD,which last for at least three month.