Expression Of Long No-coding RNA TUG1 In Rectal Cancer And Its Clinical Significance

Object To detect the expression of Long-noncoding RNA(lncRNA)Taurine upregulated gene 1(TUG1)in rectal cancer and to analyze its relationship with clinicopathological parameters in patients with rectal cancer,To explore its clinical significance in rectal cancer;Methods We collected 58 cases of resected rectal cancer tissues and their pericarcinoma tissues from the Department of General Surgery,Anhui Provincal Hospital from June 2013 to December 2013.The qRT-PCR assay was used to detect the expression level of lncRNA TUG1 in cancer tissues and adjacent tissues.Clinicopathological data were collected to analyze the relationship between lncRNA TUG1 expression and clinicopathological parameters.Results The expression of lncRNA TUG1 in rectal cancer tissues was higher than that in adjacent tissues(P <0.05).The expression level of lncRNA TUG1 was not related to other clinicopathological parameters such as sex,age,tumor size,but correlated with lymph node metastasis,distant metastasis and tumor Differentiation and TNM stage(P <0.05).Kaplan-Meier analysis showed that the OS and DFS of patients with high expression of TUG1 were significantly shorter than those with low expression of TUG1,and confirmed that the high expression of TUG1 was associated with poor OS and DFS in patients with rectal cancer;Multivariate analysis showed that lncRNA TUG1 was an independent prognostic factor for rectal cancer.Conclusions lncRNA TUG1 may play an oncogene role in the development and progression of rectal cancer.The detection of lncRNA TUG1 is of potential value in the prognosis of rectal cancer patients.