Efficacy Evaluation On Comprehensive Program For Early And Mid-stage Diabetic Kidney Disease By Data Envelopment Analysis

ObjectiveThis research utilized DEA to evaluate the relative validity of two different TCM comprehensive regimens in patients with early and mid-stage type2 diabetic kidney disease with Qi-Yin deficiency of blood stasis syndrome.We want to explore more effective new drugs of early and mid-stage type 2 diabetic kidney disease with Qi-Yin deficiency blood stasis syndrome.And to provide a clinical basis for new Chinese medicine treatment of early and mid-stage type 2 diabetic kidney disease.MethodsIn this study,43 patients with early and mid-stage type 2 diabetic kidney disease with Qi-Yin deficiency of blood stasis syndrome were enrolled and randomly divided into the core drug group and the new prescriptions group.These two groups of patients were given appropriate individual basis of treatment based on the disease program,including education,a reasonable diet,hypoglyc-emic,antihypertensive,lipid-lowering.In addition to the basic treatment programs,the core drug group added a core set of drugs that was concluded by Chinese medicine inheritance ancillary platform for 2 diabetic kidney disease with Qi-Yin deficiency of blood stasis syndrome(the main components included astragalus,radix rehmanniae,salvia,yam,angelica,etc,and the specific amount and prescription according to individual circumstances appropriate additions and subtractions);At the same time added ear points treatment(acupoints included the pancreas,endocrine,triple burner,kidney,lung,spleen,stomach,depending on personal circumstances adjustment).The new prescriptions group was given the basic treatment programs,added another drugs that was concluded by Chinese medicine inheritance ancillary platform for 2 diabetic kidney disease with Qi-Yin deficiency of blood stasis syndrome(the main components included rehmannia,atractylodes,yam,Chuanxiong,safflower and so on,and the specific amount and prescription according to individual circumstances appropriate additions and subtractions);At the same time added ear points treatment(acupoints include the pancreas,endocrine,triple burner,kidney,lung,spleen,stomach,depending on personal circumstances adjustment).The course of treatment was eight weeks.After the course of treatment,DEA was used to analyze the input and output indicators of two groups of patients,then draw the conclusion.Results(1)Analysis of Scale efficiency results showed that the mean efficiencies(θ)of the C~2R model and the BC~2model of the core drug group were 0.717 and0.791.The mean efficiency(θ)of the C~2R model and the BC~2model of the new prescriptions group were 0.625 and 0.697.The core drug group’s scale benefit is superior to that of the new prescriptions group.(2)From the slack variable analysis results,in the output of 1,2,5,6,the core drug group was closer to the ideal state that compared with the new group of traditional Chinese medicine,the new prescriptions group in the output of3 and 7 were closer to the ideal state than the core drug group.ConclusionThe results of DEA of two groups showed that comprehensive regimens of the core drug treatment group was superior to the new prescriptions group.The efficacy of the core drug is better than that of the new prescriptions.In improving 24-hour urinary protein,24-hour urinary albumin,fasting blood glucose,2 hours postprandial blood glucose,the core drug group was closer to the ideal state.The new prescriptions group was closer to the ideal state in terms of improving serum creatinine and TCM syndrome scores.