Correlation Between BMI And The Clinicopathological Features Of Female Hormone Receptor-positive Breast Cancer

ObjectiveTo collect the clinicopathological data of female hormone receptor-positive breast cancer,and to explore the relationship between body mass index(BMI)and clinicopathological characteristics of female hormone receptor-positive breast cancer.MethodsThe clinical data of 112 cases of female hormone receptor-positive breast cancer,which were Pathologically confirmed in the fujian provincial hospital from2013.01.01 to 2013.12.31 were reviewed.No preoperative adjuvant treatment was performed in all cases.Body mass index(BMI)and other clinicopathological features of all cases including age,menopause,diabetes,tumor size,lymph node metastasis,clinical stage,histological grade,Ki67 status,HER-2,vessel invasion,were collected,and the correlation between the body mass index and tclinicopathological characteristics of female hormone receptor-positive breast cancer was analyzed.Results1.There were 61 cases(54.46%)of overweight and obesity(BMI≥23kg/m~2)in 112female hormone receptor positive breast cancer,and 51 cases(45.54%)with BMI<23kg/m~2.Univariate analysis showed there were no correlation between overweight and obesity(BMI≥23kg/m~2)and age(P=0.136),menopause(P=0.125),diabetes(P=0.518),tumor size(P=0.119),clinical stage(P=0.448),histological grade(P=0.084),Ki67(P=0.270),HER-2(P=0.332),and vessel invasion(P=0.486)in female hormone receptor-positive breast cancer,while there was a positive correlation between BMI and axillary lymph node metastasis(P=0.010).2.Univariate analysis of the factors association with axillary lymph node metastasis in female hormone receptor-positive breast cancer indicated that:There were no correlation between axillary lymph node metastasis in female hormone receptor-positive breast cancer and age(P=0.880),menopause(P=0.865),diabetes(P=0.880),histological grade(P=0.281),Ki67(P=0.054),HER-2(P=0.531),and vessel invasion(P=0.313),while there were close correlation between lymph node metastasis and BMI≥23kg/m~2(P=0.03),tumor size(P=0.02).3.The results of multivariate analysis by Logistic regression analysis showed that body mass index(0R=2.773,95%CI=1.220-6.304,P=0.015)and tumor size(0R=2.709,95%CI=1.191-6.162,P=0.017)were independent risk factors of the lymph node metastasis in female hormone receptor-positive breast cancer.Conclusion1.Body mass index was close related to female hormone receptor-positive breast cancer.High body mass index was found to have higher axillary lymph node metastasis rate.2.Axillary lymph node metastasis in female hormone receptor-positive breast cancer was correlated with body mass index and tumor size.3.body mass index was an independent risk factor affecting lymph node metastasis of female hormone receptor-positive breast cancer.