| Objective.To evaluate the efficiency and safety of intravitreal anti-VEGF combined with laser versus laser alone for treatment of macular edema due to retinal vein occlusion.Methods.A comprehensive search in EMbase、The Cochrane Library、Pubmed、CBM、Wan Fang Database、CNKI was conducted to identify potentially relevant randomized controlled trials published before November 2017 without any restriction on language.The Jadad Scale and the Cochrane Assessing Risk of Bias Tool are adopted to evaluate the methodological quality of the pooled trails,and publication bias was explored by searching for asymmetry in the funnel plot.Finally a meta-analysis of the pooled data was conducted by using the Rev Man 5.3 software.Results.A total of 662 eyes in 12 trials published from 2011 to 2017 were analyzed in this study,the enrolled eyes were divided into two groups:383 eyes in the anti-VEGF combine with laser group(experimental group)and 279 eyes in the only laser group(control group).The result of meta-analysis showed that: Comparing anti-VEGF with GLP versus GLP in improving Log MAR BCVA at 1 month(weighted mean difference [WMD],0.29 log MAR;95% confidence interval [CI],0.16 to 0.43;P<0.00001),3 month(WMD,0.21 log MAR;95%CI,0.11 to 0.32;P=0.003),and 6 month during the follow-up(WMD,0.24 log MAR;95%CI,0.06 to 0.43;P<0.00001)in patients with RVO-associated macular edema.Comparing anti-VEGF with GLP versus GLP in reducing CMT at 1 month(WMD,174.78;95%CI,122.46 to 227.10;P<0.00001),3 month(WMD,127.63;95%CI,80.97 to 174.30;P<0.00001),and 6 month during the follow-up(WMD,128.55;95%CI,58.29 to 198.80;P<0.00001)in patients with RVOassociate macular edema.Comparing anti-VEGF with GLP versus GLP,there is significance in either improving BCVA and reducing CMT throughout the follow-up periods.Conclusions.The intravitreal injection of anti-VEGF with laser is a safe and efficient intervention.It is significantly better than laser therapy,which can eliminate ocular edema and improve the BCVA. |
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