Association Between Fine Particulate Matter And Hypertensive Disorder Complicating Pregnancy

Objective: Hypertensive disorder complicating pregnancy(HDCP)is a common obstetric complication with serious consequences for both mother and infant.Maternal exposure to high levels of air pollution may trigger HDP,but relevant epidemiological evidence is very limited.This study was designed to analyze the factors that affected hypertensive disorder complicating pregnancy and examined effects of residential exposure to PM2.5 on hypertensive disorder complicating pregnancy,and finally to provide a theoretical basis prevention of adverse obstetric outcomes and the development of relevant environmental standards in China.METHODS: We conducted this study in 5211 pregnant women,who were recruited in 2012-2014 from the Healthy Baby Cohort(HBC)in Wuhan City,China.Trimester-specific PM2.5 exposure were estimated based on 24-hour exposure level at residential address using inverse-distance weighting interpolation.Information of participants was collected through the questionnaire and medical records.We used logistic regression to estimate effects of PM2.5 exposures on HDCP.Results: 1.The result of multi-factor logistic regression analysis showed that higher level of education(OR = 0.56)and iron supplement during pregnancy(OR = 0.57)were protective factors of HDCP,and age>30(OR = 1.48),overweight(OR = 4.06),excessive weight gain during pregnancy(OR = 1.06)increased the risk of HDCP.2.A significant association was observed between second trimester PM2.5 exposure and risk of HDCP [adjusted odds ratio(OR)=1.70 for the highest quartile,95% confidence interval(CI): 1.03,2.82].Adjusted ORs for the highest versus lowest quartile from stratified analyses were 2.17(95%CI: 1.26-3.73),2.08(95%CI: 1.13-3.84)and 2.30(95%CI: 1.07-4.90)for mothers who were primiparous,non-overweight and have lower household income.Conclusion: Age,prepregnancy BMI,excessive weight gain,education level and iron supplement during pregnancy were important factors affecting HDCP.Second trimester exposure to PM2.5 may potentially increase the risk of HDCP,particularly in mothers who were primiparous,non-obese and have lower household income.